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Quantitative MRI for Analysis of Active Multiple Sclerosis Lesions without Gadolinium-Based Contrast Agent
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences.ORCID iD: 0000-0002-8857-5698
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
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2016 (English)In: American Journal of Neuroradiology, ISSN 0195-6108, E-ISSN 1936-959X, Vol. 37, no 1, 94-100 p.Article in journal (Refereed) PublishedText
Abstract [en]

BACKGROUND AND PURPOSE: Contrast-enhancing MS lesions are important markers of active inflammation in the diagnostic work-up of MS and in disease monitoring with MR imaging. Because intravenous contrast agents involve an expense and a potential risk of adverse events, it would be desirable to identify active lesions without using a contrast agent. The purpose of this study was to evaluate whether pre-contrast injection tissue-relaxation rates and proton density of MS lesions, by using a new quantitative MR imaging sequence, can identify active lesions. MATERIALS AND METHODS: Forty-four patients with a clinical suspicion of MS were studied. MR imaging with a standard clinical MS protocol and a quantitative MR imaging sequence was performed at inclusion (baseline) and after 1 year. ROIs were placed in MS lesions, classified as nonenhancing or enhancing. Longitudinal and transverse relaxation rates, as well as proton density were obtained from the quantitative MR imaging sequence. Statistical analyses of ROI values were performed by using a mixed linear model, logistic regression, and receiver operating characteristic analysis. RESULTS: Enhancing lesions had a significantly (P < .001) higher mean longitudinal relaxation rate (1.22 0.36 versus 0.89 +/- 0.24), a higher mean transverse relaxation rate (9.8 +/- 2.6 versus 7.4 +/- 1.9), and a lower mean proton density (77 +/- 11.2 versus 90 +/- 8.4) than nonenhancing lesions. An area under the receiver operating characteristic curve value of 0.832 was obtained. CONCLUSIONS: Contrast-enhancing MS lesions often have proton density and relaxation times that differ from those in nonenhancing lesions, with lower proton density and shorter relaxation times in enhancing lesions compared with nonenhancing lesions.

Place, publisher, year, edition, pages
AMER SOC NEURORADIOLOGY , 2016. Vol. 37, no 1, 94-100 p.
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Clinical Medicine
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URN: urn:nbn:se:liu:diva-124482DOI: 10.3174/ajnr.A4501ISI: 000367466500019PubMedID: 26471751OAI: oai:DiVA.org:liu-124482DiVA: diva2:899706
Note

Funding Agencies|National Science and Engineering Research Council; University of Linkoping; University Hospital Research Funds

Available from: 2016-02-02 Created: 2016-02-01 Last updated: 2016-02-19

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Blystad, IdaHåkansson, IreneTisell, AndersErnerudh, JanSmedby, ÖrjanLundberg, PeterLarsson, Elna-Marie
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Center for Medical Image Science and Visualization (CMIV)Faculty of Medicine and Health SciencesDivision of Radiological SciencesDivision of Neuro and Inflammation ScienceDepartment of Medical and Health SciencesDepartment of Radiation PhysicsDepartment of Clinical Immunology and Transfusion MedicineDepartment of Radiology in Linköping
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American Journal of Neuroradiology
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