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Atypical fractures, a biased perspective
Linköping University, Department of Clinical and Experimental Medicine. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
2016 (English)In: Injury, ISSN 0020-1383, E-ISSN 1879-0267, Vol. 47, no 1, S28-S30 p.Article in journal (Refereed) PublishedText
Abstract [en]

When stress fractures started to show up in the femurs of elderly ladies, it was soon evident that bisphosphonate use lay behind, and the absolute risk increase due to bisphosphonate use was reasonably well estimated already in 2008. Thereafter followed a period of confusion: the term atypical fracture was introduced, with a definition so vague that the true stress fractures tended to disappear in a cloud of ambiguity. This cast doubt on the association with bisphosphonates. The association was then re-established by large epidemiological studies based on radiographic adjudication. Atypical fractures are largely caused by bisphosphonates. With a correct indication, bisphosphonates prevent many more fractures than they cause, at least during the first years of use. With an incorrect indication they are likely to cause more harm than good. (C) 2016 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2016. Vol. 47, no 1, S28-S30 p.
Keyword [en]
atypical fractures; bisphosphonates; proximal femoral fractures; osteoporosis
National Category
URN: urn:nbn:se:liu:diva-124476DOI: 10.1016/S0020-1383(16)30007-9ISI: 000367533000007PubMedID: 26768286OAI: diva2:899752

Funding Agencies|Eli Lilly; Amgen

Available from: 2016-02-02 Created: 2016-02-01 Last updated: 2016-02-09

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Aspenberg, Per
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Department of Clinical and Experimental MedicineDepartment of Orthopaedics in Linköping
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