Time since heart failure diagnosis influences outcomes more than age when handling heart failure patients: Results from the UPSTEP study
2016 (English)Manuscript (preprint) (Other academic)
Background: Heart failure (HF) is a life-threatening condition and optimal handling is necessary to reduce risk of therapy failure.
Objectives: The aims of this study were (I) to evaluate the impact of patient age on clinical outcomes, (II) to evaluate the impact of duration of the HF disease on outcomes, and (III) to evaluate the impact of age and HF duration on B-type Natriuretic Peptide (BNP) concentration.
Methods and Results: With data from the UPSTEP (Use of PeptideS in Tailoring hEart failure Project) study we retrospectively evaluated how age and HF duration affected HF outcome. HF duration was divided into <1 year (group 1), 1-5 years (group 2) and >5 years (group 3). The multivariate Cox proportional hazard regression analysis showed that HF duration influenced outcome more than age, even when adjusted for comorbidities(<1 year versus >5 years: HR 1.65; 95 % CI 1.28-2.14; p <0.0002) on HF mortality and hospitalizations. The influence of age on BNP showed increased BNP as age increased. However, there was a significant effect on BNP concentration comparing HF duration of < one year to HF duration >five years even when adjusted for age.
Conclusions: Patients with longer HF duration had significantly worse outcome compared to those with short duration, even when adjusted for patient age and comorbidities. Age itself did not influence outcome in this evaluation. Age had impact on BNP concentration; however BNP concentration increased as HF duration increased even when adjusted for age.
Place, publisher, year, edition, pages
Heart failure, B-type natriuretic peptides, age, heart failure duration
Cardiac and Cardiovascular Systems
IdentifiersURN: urn:nbn:se:liu:diva-124559OAI: oai:DiVA.org:liu-124559DiVA: diva2:900058