Anticancer effects of nanometallic oxides and their ligands with photosensitizers in osteosarcoma cells
2015 (English)In: Journal of Optoelectronics and Advanced Materials, ISSN 1454-4164, E-ISSN 1841-7132, Vol. 17, no 11-12, 1808-1815 p.Article in journal (Refereed) PublishedText
We studied the cytotoxic effects in Osteosarcoma (U2OS) cells to different nanosized metallic oxides e.g. zinc oxide nanowires (ZnO-NRs), manganese di-oxide nanowires (MnO2 NWs), ferric oxide nanoparticles (Fe2O3 NPs) individually and their connplexed forms with photosensitizers photofrin (R), 5-Aminolevulinic acid (5-ALA), and protoporphyrin IX (Pp IX). Cellular toxicity was assayed by cellular morphology, reactive oxygen species (ROS) detection, MTT assay under ultraviolet (UV), visible light and laser exposed conditions. Prominent cell death with above cited nanomaterials in their complexed forms with Photosensitizer was observed in labeled U2OS cells. This cell death might be due to their synergetic effect via the release of singlet oxygen species in Osteosarcoma cells showing their anticancer-cell effects.
Place, publisher, year, edition, pages
NATL INST OPTOELECTRONICS , 2015. Vol. 17, no 11-12, 1808-1815 p.
Osteosarcoma cell; reactive oxygen species (ROS); MTT assay; photodynamic therapy (PDT)
Electrical Engineering, Electronic Engineering, Information Engineering
IdentifiersURN: urn:nbn:se:liu:diva-124652ISI: 000368046700030OAI: oai:DiVA.org:liu-124652DiVA: diva2:901581
Funding Agencies|Deanship of Scientific Research at King Saud University [RGP -VPP-293]2016-02-082016-02-082016-02-15