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Anticancer effects of nanometallic oxides and their ligands with photosensitizers in osteosarcoma cells
Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering. GC University, Pakistan.
Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering.
GC University, Pakistan.
King Saud University, Saudi Arabia; National Institute Laser and Optron, Pakistan.
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2015 (English)In: Journal of Optoelectronics and Advanced Materials, ISSN 1454-4164, E-ISSN 1841-7132, Vol. 17, no 11-12, 1808-1815 p.Article in journal (Refereed) PublishedText
Abstract [en]

We studied the cytotoxic effects in Osteosarcoma (U2OS) cells to different nanosized metallic oxides e.g. zinc oxide nanowires (ZnO-NRs), manganese di-oxide nanowires (MnO2 NWs), ferric oxide nanoparticles (Fe2O3 NPs) individually and their connplexed forms with photosensitizers photofrin (R), 5-Aminolevulinic acid (5-ALA), and protoporphyrin IX (Pp IX). Cellular toxicity was assayed by cellular morphology, reactive oxygen species (ROS) detection, MTT assay under ultraviolet (UV), visible light and laser exposed conditions. Prominent cell death with above cited nanomaterials in their complexed forms with Photosensitizer was observed in labeled U2OS cells. This cell death might be due to their synergetic effect via the release of singlet oxygen species in Osteosarcoma cells showing their anticancer-cell effects.

Place, publisher, year, edition, pages
NATL INST OPTOELECTRONICS , 2015. Vol. 17, no 11-12, 1808-1815 p.
Keyword [en]
Osteosarcoma cell; reactive oxygen species (ROS); MTT assay; photodynamic therapy (PDT)
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:liu:diva-124652ISI: 000368046700030OAI: oai:DiVA.org:liu-124652DiVA: diva2:901581
Note

Funding Agencies|Deanship of Scientific Research at King Saud University [RGP -VPP-293]

Available from: 2016-02-08 Created: 2016-02-08 Last updated: 2016-02-15

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Kishwer, SultanaNour, OmerWillander, Magnus
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