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Risk of basal cell carcinoma in Swedish organ transplant recipients: a population-based study
Karolinska University of Labs, Sweden; Karolinska Institute, Sweden.
Karolinska Institute, Sweden.
Region Östergötland, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics. Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
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2016 (English)In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 174, no 1, 95-103 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background Risk of basal cell carcinoma (BCC) has been reported to be several-fold increased among organ transplant recipients (OTRs). However, due to lack of reliable BCC registration, population-based risk estimates are scarce. Objectives To characterize risk of BCC among OTRs compared with the general population, and contrast with risk of cutaneous squamous cell carcinoma (SCC). Subjects and methods OTRs transplanted during 2004-2011 were identified through national healthcare registers and linked with the nationwide Swedish BCC Register initialized in 2004. Relative risk of BCC was expressed as standardized incidence ratios (SIR) with 95% confidence intervals (CI). Results Altogether, 4023 transplanted patients developed 341 BCCs during follow-up. Compared with the general population, the relative risk of BCC was increased sixfold (SIR 6.1, 95% CI 5.4-6.9). The risk was higher in kidney and heart/lung than in liver recipients (SIRkidney 7.2, 6.3-8.3; SIRheart/lung 5.8, 4.0-8.2; SIRliver 2.6, 1.7-4.0), and risk increased with time since transplantation (P-trend < 0.01). The SCC to BCC ratio was 1 : 1.7 and BCC developed earlier after transplantation than SCC. Distribution of anatomical sites and histological types did not differ substantially between OTR- and population-BCCs. Conclusions Risk of BCC was strikingly elevated in OTRs compared with the general population. Risk was higher in kidney recipients and increased with follow-up time. These findings support a tumour-promoting effect of immunosuppressive drugs in BCC development. The low SCC to BCC ratio was possibly attributed to short follow-up time.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 174, no 1, 95-103 p.
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-124636DOI: 10.1111/bjd.14153ISI: 000368480300016PubMedID: 26333521OAI: oai:DiVA.org:liu-124636DiVA: diva2:901759
Note

Funding Agencies|Welander Foundation; Westerberg Foundation; Strategic Research Program in Epidemiology at Karolinska Institutet, Stockholm, Sweden

Available from: 2016-02-09 Created: 2016-02-08 Last updated: 2016-02-09

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Department of Clinical Pathology and Clinical GeneticsDepartment of Clinical and Experimental MedicineFaculty of Medicine and Health Sciences
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British Journal of Dermatology
Clinical Medicine

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