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Isotonic saline in elderly men: an open-labelled controlled infusion study of electrolyte balance, urine flow and kidney function
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping. Sodertalje Hospital, Sweden.
Soder Sjukhuset, Sweden.
Karolinska Institute, Sweden.
Soder Sjukhuset, Sweden.
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2016 (English)In: Anaesthesia, ISSN 0003-2409, E-ISSN 1365-2044, Vol. 71, no 2, 155-162 p.Article in journal (Refereed) PublishedText
Abstract [en]

Isotonic saline is a widely-used infusion fluid, although the associated chloride load may cause metabolic acidosis and impair kidney function in young, healthy volunteers. We wished to examine whether these effects also occurred in the elderly, and conducted a crossover study in 13 men with a mean age of 73 years (range 66-84), who each received intravenous infusions of 1.5 l of Ringers acetate and of isotonic saline. Isotonic saline induced mild changes in plasma sodium (mean +1.5 mmol.l(-1)), plasma chloride (+3 mmol.l(-1)) and standard bicarbonate (-2 mmol.l(-1)). Three hours after starting the infusions, 68% of the Ringers acetate and 30% of the infused saline had been excreted (p < 0.01). The glomerular filtration rate increased in response to both fluids, but more after the Ringers acetate (p < 0.03). Pre-infusion fluid retention, as evidenced by high urinary osmolality (> 700 and/or creatinine (> 7 mmol.l(-1)), was a strong factor governing the responses to both fluid loads.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 71, no 2, 155-162 p.
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-124625DOI: 10.1111/anae.13301ISI: 000368004000006PubMedID: 26669730OAI: diva2:901798

Funding Agencies|Stockholm City Council; Kleberg Foundation

Available from: 2016-02-09 Created: 2016-02-08 Last updated: 2016-02-09

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Hahn, Robert
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Division of Drug ResearchFaculty of Medicine and Health SciencesDepartment of Anaesthesiology and Intensive Care in Linköping
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