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High-Resolution Laser Doppler Measurements of Microcirculation in the Deep Brain Structures: A Method for Potential Vessel Tracking.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV). (MINT)ORCID iD: 0000-0002-0012-7867
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering. University of Applied Sciences and Arts Northwestern Switzerland, Muttenz , Switzerland. (MINT)
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering. (MINT)
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
2016 (English)In: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 94, no 1, 1-9 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Laser Doppler flowmetry (LDF) can be used to measure cerebral microcirculation in relation to stereotactic deep brain stimulation (DBS) implantations.

OBJECTIVE: To investigate the microcirculation and total light intensity (TLI) corresponding to tissue grayness in DBS target regions with high-resolution LDF recordings, and to define a resolution which enables detection of small vessels.

METHODS: Stereotactic LDF measurements were made prior to DBS implantation with 0.5-mm steps in the vicinity to 4 deep brain targets (STN, GPi, Vim, Zi) along 20 trajectories. The Mann-Whitney U test was used to compare the microcirculation and TLI between targets, and the measurement resolution (0.5 vs. 1 mm). The numbers of high blood flow spots along the trajectories were calculated.

RESULTS: There was a significant difference (p < 0.05) in microcirculation between the targets. High blood flow spots were present at 15 out of 510 positions, 7 along Vim and GPi trajectories, respectively. There was no statistical difference between resolutions even though both local blood flow and TLI peaks could appear at 0.5-mm steps.

CONCLUSIONS: LDF can be used for online tracking of critical regions presenting blood flow and TLI peaks, possibly relating to vessel structures and thin laminas along stereotactic trajectories.

Place, publisher, year, edition, pages
S. Karger, 2016. Vol. 94, no 1, 1-9 p.
Keyword [en]
Deep brain stimulation · Laser Doppler flowmetry ·Stereotactic neurosurgery · Microcirculation · Navigation
National Category
Biomedical Laboratory Science/Technology Neurology
Identifiers
URN: urn:nbn:se:liu:diva-124691DOI: 10.1159/000442894ISI: 000373869900001PubMedID: 26795207OAI: oai:DiVA.org:liu-124691DiVA: diva2:902056
Note

Funding agencies:  Swedish Research Council [621-2013-6078]; Parkinson Foundation at Linkoping University; Swiss National Science Foundation [205321-135285]

Available from: 2016-02-10 Created: 2016-02-10 Last updated: 2017-11-30Bibliographically approved

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Wårdell, KarinHemm-Ode, SimoneRejmstad, PeterZsigmond, Peter

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Wårdell, KarinHemm-Ode, SimoneRejmstad, PeterZsigmond, Peter
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Biomedical InstrumentationFaculty of Science & EngineeringCenter for Medical Image Science and Visualization (CMIV)Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Neurosurgery
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Stereotactic and Functional Neurosurgery
Biomedical Laboratory Science/TechnologyNeurology

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