liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Food intake, tumor growth, and weight loss in EP2 receptor subtype knockout mice bearing PGE2-producing tumors
Department of Surgery, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden..
Department of Surgery, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden..
Region Östergötland, Local Health Care Services in Central Östergötland, Department of Geriatric Medicine in Linköping. Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-2230-4174
Department of Surgery, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden..
Show others and affiliations
2015 (English)In: Physiological Reports, E-ISSN 2051-817X, ISSN 2051-817X, Vol. 3, no 7, 1-7 p., e12441Article in journal (Refereed) Published
Abstract [en]

Previous studies in our laboratory have demonstrated that prostaglandin (PG) E2 is involved in anorexia/cachexia development in MCG 101 tumor‐bearing mice. In the present study, we investigate the role of PGE receptor subtype EP2 in the development of anorexia after MCG 101 implantation in wild‐type (EP2+/+) or EP2‐receptor knockout (EP2−/−) mice. Our results showed that host absence of EP2 receptors attenuated tumor growth and development of anorexia in tumor‐bearing EP2 knockout mice compared to tumor‐bearing wild‐type animals. Microarray profiling of the hypothalamus revealed a relative twofold change in expression of around 35 genes including mRNA transcripts coding for Phospholipase A2 and Prostaglandin D2 synthase (Ptgds) in EP2 receptor knockout mice compared to wild‐type mice. Prostaglandin D2 synthase levels were increased significantly in EP2 receptor knockouts, suggesting that improved food intake may depend on altered balance of prostaglandin production in hypothalamus since PGE2 and PGD2 display opposing effects in feeding control.

Place, publisher, year, edition, pages
2015. Vol. 3, no 7, 1-7 p., e12441
Keyword [en]
Anorexia, cachexia, EP receptor, hypothalamus, microarray analysis, Prostaglandin D synthase
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-125249DOI: 10.14814/phy2.12441PubMedID: 26197930OAI: oai:DiVA.org:liu-125249DiVA: diva2:903987
Available from: 2016-02-17 Created: 2016-02-17 Last updated: 2017-11-30

Open Access in DiVA

fulltext(411 kB)39 downloads
File information
File name FULLTEXT02.pdfFile size 411 kBChecksum SHA-512
575b46a71b592ffd8a04255391a16c8552ec56ac24312c167da7449bc0b166b702f093da2a01121aeffc365e3758af6155930562aff06fca58f58db0878dabab
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Nilsberth, Camilla

Search in DiVA

By author/editor
Nilsberth, Camilla
By organisation
Department of Geriatric Medicine in LinköpingDivision of Cell BiologyFaculty of Medicine and Health Sciences
In the same journal
Physiological Reports
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 39 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 274 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf