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Pain in the Blood? Envisioning Mechanism-Based Diagnoses and Biomarkers in Clinical Pain Medicine.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-4420-418X
2015 (English)In: Diagnostics, ISSN 1777-781X, Vol. 5, no 1, 84-95 p.Article in journal, News item (Refereed) Published
Abstract [en]

Chronic pain is highly prevalent, and pain medicine lacks objective biomarkers to guide diagnosis and choice of treatment. The current U.S. "opioid epidemic" is a reminder of the paucity of effective and safe treatment options. Traditional pain diagnoses according to the International Classification of Diseases are often unspecific, and analgesics are often prescribed on a trial-and-error basis. In contrast to this current state of affairs, the vision of future mechanism-based diagnoses of chronic pain conditions is presented in this non-technical paper, focusing on the need for biomarkers and the theoretical complexity of the task. Pain is and will remain a subjective experience, and as such is not objectively measurable. Therefore, the concept of "noci-marker" is presented as an alternative to "pain biomarker", the goal being to find objective, measurable correlates of the pathophysiological processes involved in different chronic pain conditions. This vision entails a call for more translational pain research in order to bridge the gap between clinical pain medicine and preclinical science.

Place, publisher, year, edition, pages
2015. Vol. 5, no 1, 84-95 p.
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URN: urn:nbn:se:liu:diva-125466DOI: 10.3390/diagnostics5010084PubMedID: 26854144OAI: diva2:906402
Available from: 2016-02-24 Created: 2016-02-24 Last updated: 2016-03-07

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Bäckryd, Emmanuel
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Division of Community MedicinePain and Rehabilitation CenterFaculty of Health Sciences

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