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Non-contact scanning diffuse correlation tomography system for three-dimensional blood flow imaging in a murine bone graft model.
Institute of Optics, University of Rochester.
ICFO- Institut de Ciències Fotòniques.
ICFO- Institut de Ciències Fotòniques.
Department of Biomedical Engineering, University of Rochester.
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2015 (English)In: Biomedical Optics Express, ISSN 2156-7085, E-ISSN 2156-7085, Vol. 6, no 7Article in journal (Refereed) Published
Abstract [en]

A non-contact galvanometer-based optical scanning system for diffuse correlation tomography was developed for monitoring bone graft healing in a murine femur model. A linear image reconstruction algorithm for diffuse correlation tomography was tested using finite-element method based simulated data and experimental data from a femur or a tube suspended in a homogeneous liquid phantom. Finally, the non-contact system was utilized to monitor in vivo blood flow changes prior to and one week after bone graft transplantation within murine femurs. Localized blood flow changes were observed in three mice, demonstrating a potential for quantification of longitudinal blood flow associated with bone graft healing.

Place, publisher, year, edition, pages
2015. Vol. 6, no 7
National Category
Medical Image Processing
URN: urn:nbn:se:liu:diva-125653DOI: 10.1364/BOE.6.002695PubMedID: 26203392OAI: diva2:907607
Available from: 2016-02-29 Created: 2016-02-29 Last updated: 2016-05-30

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Johansson, Johannes
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