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Regulation of CD8+T-cell cytotoxicity in HIV-1 infection
University of Malaya, Malaysia.
University of Penn, PA 19104 USA.
Karolinska Institute, Sweden.
University of Malaya, Malaysia.
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2015 (English)In: Cellular Immunology, ISSN 0008-8749, E-ISSN 1090-2163, Vol. 298, no 1-2, 126-133 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Understanding the mechanisms involved in cellular immune responses against control of human immunodeficiency virus (HIV) infection is key to development of effective immunotherapeutic strategies against viral proliferation. Clear insights into the regulation of cytotoxic CD8+ T cells is crucial to development of effective immunotherapeutic strategies due to their unique ability to eliminate virus-infected cells during the course of infection. Here, we reviewed the roles of transcription factors, co-inhibitory molecules and regulatory cytokines following HIV infection and their potential significance in regulating the cytotoxic potentials of CD8+ T cells. (C) 2015 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2015. Vol. 298, no 1-2, 126-133 p.
Keyword [en]
HIV; CD8+T cells; Perforin; Cytotoxicity; Transcription factors; Cytokines
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-125694DOI: 10.1016/j.cellimm.2015.10.009ISI: 000369168400016PubMedID: 26520669OAI: oai:DiVA.org:liu-125694DiVA: diva2:908196
Available from: 2016-03-01 Created: 2016-02-29 Last updated: 2016-03-01

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Larsson, Marie
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health Sciences
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