Pedometer-determined physical activity level and change in arterial stiffness in Type 2 diabetes over 4 years
2016 (English)In: Diabetic Medicine, ISSN 0742-3071, E-ISSN 1464-5491, Vol. 33, no 7, 992-997 p.Article in journal (Refereed) PublishedText
Aim To explore prospectively the correlation between the level of pedometer-determined physical activity at the start of the study and the change in pulse wave velocity from baseline to 4 years later in people with Type 2 diabetes.
Methods We analysed data from 135 men and 53 women with Type 2 diabetes, aged 54–66 years. Physical activity was measured with waist-mounted pedometers on 3 consecutive days and the numbers of steps/day at baseline were classified into four groups: <5000 steps/day, 5000–7499 steps/day, 7500–9999 steps/day and ≥10 000 steps/day. Pulse wave velocity was measured using applanation tonometry over the carotid and femoral arteries at baseline and after 4 years.
Results The mean (±sd; range) number of steps/day was 8022 (±3765; 956–20 921). The participants with the lowest level of physical activity had a more pronounced increase in the change in pulse wave velocity compared with the participants with the highest. When change in pulse wave velocity was analysed as a continuous variable and adjusted for sex, age, diabetes duration, HbA1c, BMI, systolic blood pressure, pulse wave velocity at baseline, β-blocker use, statin use, unemployment, smoking and diabetes medication, the number of steps/day at baseline was significantly associated with a less steep increase in change in pulse wave velocity (P=0.005). Every 1000 extra steps at baseline corresponded to a lower increase in change in pulse wave velocity of 0.103 m/s.
Conclusions We found that a high level of pedometer-determined physical activity was associated with a slower progression of arterial stiffness over 4 years in middle-aged people with Type 2 diabetes.
Place, publisher, year, edition, pages
John Wiley & Sons, 2016. Vol. 33, no 7, 992-997 p.
Endocrinology and Diabetes Family Medicine Geriatrics Sport and Fitness Sciences Cardiac and Cardiovascular Systems
IdentifiersURN: urn:nbn:se:liu:diva-125910DOI: 10.1111/dme.12873ISI: 000379930900018PubMedID: 26227869OAI: oai:DiVA.org:liu-125910DiVA: diva2:909995
Funding agencies: Medical Research Council of Southeast Sweden; Centre for Medical Image Science and Visualization (CMIV), Linkoping University; GE Healthcare; Swedish Heart-Lung Foundation; Swedish Research Council ; King Gustaf V and Queen Victoria Freemason Found2016-03-082016-03-082016-08-20Bibliographically approved