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The accuracy of quantitative parameters in Tc-99m-MAG3 dynamic renography: a national audit based on virtual image data
Lund University, Sweden.
EQUALIS AB, Sweden; Lund University, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
Linköping University, Department of Medical and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 36, no 2, 146-154 p.Article in journal (Refereed) PublishedText
Abstract [en]

Assessment of image analysis methods and computer software used in Tc-99m-MAG3 dynamic renography is important to ensure reliable study results and ultimately the best possible care for patients. In this work, we present a national multicentre study of the quantification accuracy in Tc-99m-MAG3 renography, utilizing virtual dynamic scintigraphic data obtained by Monte Carlo-simulated scintillation camera imaging of digital phantoms with time-varying activity distributions. Three digital phantom studies were distributed to the participating departments, and quantitative evaluation was performed with standard clinical software according to local routines. The differential renal function (DRF) and time to maximum renal activity (T-max) were reported by 21 of the 28 Swedish departments performing Tc-99m-MAG3 studies as of 2012. The reported DRF estimates showed a significantly lower precision for the phantom with impaired renal uptake than for the phantom with normal uptake. The T-max estimates showed a similar trend, but the difference was only significant for the right kidney. There was a significant bias in the measured DRF for all phantoms caused by different positions of the left and right kidney in the anterior-posterior direction. In conclusion, this study shows that virtual scintigraphic studies are applicable for quality assurance and that there is a considerable uncertainty associated with standard quantitative parameters in dynamic Tc-99m-MAG3 renography, especially for patients with impaired renal function.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 36, no 2, 146-154 p.
Keyword [en]
Tc-99m-MAG3; differential renal function; digital phantoms; dynamic renography; Monte Carlo imaging simulations; quality assurance
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-125796DOI: 10.1111/cpf.12208ISI: 000370199700010PubMedID: 25348641OAI: diva2:910332

Funding Agencies|Equalis

Available from: 2016-03-08 Created: 2016-03-04 Last updated: 2016-03-08

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Granerus, GöranOlsson, Anna
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Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Clinical Physiology in LinköpingDepartment of Medical and Health SciencesCenter for Medical Image Science and Visualization (CMIV)Faculty of Medicine and Health Sciences
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Clinical Physiology and Functional Imaging
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