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Prognostic significance of PLA2G4C gene polymorphism in patients with stage II colorectal cancer.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Laboratory Services, Ryhov County Hospital, Jönköping, Sweden.
Department of Surgery, Ryhov County Hospital, Jönköping Sweden.
Department of Surgery, Ryhov County Hospital, Jönköping Sweden.
Department of Clinical Microbiology, Ryohov County Hospital, Jönköping .
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2016 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 55, no 4, 474-479 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Phospholipase A2 Group IV C (PLA2G4C) catalyzes the release of certain fatty acids from phospholipids and plays a role in a range of physiological functions, such as remodeling of cell membranes and the production of prostaglandins. Furthermore, it has been proposed that PLA2G4C plays an important role in breast cancer cell chemotaxis. This study aimed to investigate the effect of a single nucleotide polymorphism (SNP) rs1549637 (T>A) of the PLA2G4C gene on the prognosis of colorectal cancer (CRC).

MATERIAL AND METHODS: Whole blood DNA was extracted from 381 patients with CRC and 618 controls, and a TaqMan SNP genotyping assay was used to determine the distribution of the genotypes. Cancer-specific and disease-free survival was analyzed by Kaplan-Meier graphs and by uni- and multivariable Cox regression.

RESULTS: The cancer-specific survival differed between the genotypes (p = 0.019) and the carriers of the A allele were associated with the highest risk of CRC death, with a hazard ratio (HR) of 1.72 [95% confidence interval (CI) 1.17-2.53, p = 0.006] compared with homozygous carriers of the T allele. This increased mortality in the carriers with the allele A was especially marked in stage II with an HR of 3.84 (95% CI 1.51-9.78, p = 0.005).

CONCLUSION: The A allele in PLA2G4C SNP (rs1549637) is associated with a worse prognosis in patients with CRC, especially in stage II disease, and it could be a potential prognostic biomarker in the planning of individual adjuvant therapy in stage II patients.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2016. Vol. 55, no 4, 474-479 p.
National Category
Cancer and Oncology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-125986DOI: 10.3109/0284186X.2015.1073350ISI: 000372125400012PubMedID: 26364726OAI: oai:DiVA.org:liu-125986DiVA: diva2:910990
Note

Funding agencies: Futurum; Academy of Healthcare; Region Jonkoping County, Sweden; Foundation of Clinical Cancer Research, Jonkoping Sweden; University College of Health Sciences, Jonkoping, Sweden

Available from: 2016-03-10 Created: 2016-03-10 Last updated: 2016-04-13

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Slind Olsen, RenateWågsäter, Dick
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Division of Drug ResearchFaculty of Medicine and Health Sciences
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