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Altered heart proteome in fructose-fed Fisher 344 rats exposed to bisphenol A.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Region Östergötland, Heart and Medicine Center, Occupational and Environmental Medicine Center. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Uppsala University, Uppsala, Sweden.
Uppsala University, Uppsala, Sweden.
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2016 (English)In: Toxicology, ISSN 0300-483X, E-ISSN 1879-3185, Vol. 347-349, 6-16 p.Article in journal (Refereed) Published
Abstract [en]

Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. Exposure-related reproductive disorders have been found, but recently it has also been suggested that BPA may be involved in obesity, diabetes, myocardial hypertrophy and myocardial infarction in humans. To mimic a modern lifestyle, female rats were fed with fructose or fructose plus BPA (0.25mg/L drinking water). The myocardial left ventricle proteome of water controls, fructose-fed and fructose-fed plus BPA supplemented rats was explored. The proteome was investigated using nano-liquid chromatography tandem mass spectrometry and two-dimensional gel electrophoresis followed by matrix assisted laser desorption/ionization mass spectrometry identification. In total, 41 proteins were significantly altered by BPA exposure compared to water or fructose controls. Principal component analysis and cellular process enrichment analysis of altered proteins suggested increased fatty acid transport and oxidation, increased ROS generation and altered structural integrity of the myocardial left ventricle in the fructose-fed BPA-exposed rats, indicating unfavorable effects on the myocardium. In conclusion, BPA exposure in the rats induces major alterations in the myocardial proteome.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 347-349, 6-16 p.
Keyword [en]
Bisphenol A; Endocrine disrupting chemicals; Fructose; Heart tissue; Proteomics
National Category
Analytical Chemistry
URN: urn:nbn:se:liu:diva-126117DOI: 10.1016/j.tox.2016.02.007ISI: 000375631700002PubMedID: 26930160OAI: diva2:911972

Funding agencies: Swedish research council Formas; County Council of Ostergotland (C-ALF); Faculty of Health Sciences in Linkoping

Available from: 2016-03-15 Created: 2016-03-15 Last updated: 2016-06-10

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Ljunggren, Stefan AIggland, MadeleineKarlsson, Helen
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Division of Neuro and Inflammation ScienceOccupational and Environmental Medicine CenterFaculty of Medicine and Health SciencesDepartment of Clinical and Experimental Medicine
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Analytical Chemistry

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