liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Umbilical cord blood concentrations of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in neonates developing hypoxic-ischemic encephalopathy.
Department of Obstetrics and Gynecology Skåne University Hospital, Institution of Clinical Sciences, Lund University, Malmö, Sweden.
Department of Neonatology, Skåne University Hospital, Institution of Clinical Sciences, Lund University, Malmö, Sweden.
Banyan Biomarkers Inc., Alachua, FL, USA.
Department of Intensive Care and Perioperative Medicine, Skåne University Hospital, Institution of Clinical Sciences, Lund University, Malmö, Sweden.
Show others and affiliations
2015 (English)In: The Journal of Maternal-Fetal & Neonatal Medicine, ISSN 1476-7058, E-ISSN 1476-4954, Vol. 29, no 11, 1822-1828 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To compare ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) concentrations in umbilical cord blood of neonates who develop Sarnat stage II-III hypoxic-ischemic encephalopathy (HIE) to healthy controls, and to relate the concentrations to the severity of neurology and long-time outcomes.

MATERIAL AND METHODS: Cord sera of 15 neonates with HIE II-III and 31 matched controls were analyzed for UCH-L1 and GFAP. Comparisons were performed for cord artery pH, amplitude-integrated electroencephalography (aEEG), stage of HIE, and death or sequelae up to an age of 6 years. Parametric and non-parametric statistics were used with a two-sided p < 0.05 considered significant.

RESULTS: Among controls no associations between biomarker concentrations and gestational age, birthweight, length of storage of cord sera and degree of hemolysis were found. No significant differences in biomarker concentrations were found between HIE neonates and controls, and no differences were found with regard to HIE stage, cord acidemia, severity of aEEG changes, or persistent sequelae or death.

CONCLUSIONS: No differences in cord blood UCH-L1 and GFAP concentrations were found between HIE neonates and controls, and no associations were found between the biomarker concentrations and the severity of disease, or whether the condition developed into a permanent or fatal injury.

Place, publisher, year, edition, pages
2015. Vol. 29, no 11, 1822-1828 p.
Keyword [en]
Brain injury marker; GFAP; HIE; UCH-L1; cord blood; encephalopathy; neonatology; pregnancy
National Category
Medical and Health Sciences Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-126149DOI: 10.3109/14767058.2015.1064108PubMedID: 26135781OAI: oai:DiVA.org:liu-126149DiVA: diva2:911991
Available from: 2016-03-15 Created: 2016-03-15 Last updated: 2016-04-05

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
In the same journal
The Journal of Maternal-Fetal & Neonatal Medicine
Medical and Health SciencesPediatrics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 234 hits
ReferencesLink to record
Permanent link

Direct link