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Different osteocalcin forms, markers of metabolic syndrome and anthropometric measures in children within the IDEFICS cohort
University of Gothenburg, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
University of Gothenburg, Sweden.
University of Gothenburg, Sweden.
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2016 (English)In: Bone, ISSN 8756-3282, E-ISSN 1873-2763, Vol. 84, 230-236 p.Article in journal (Refereed) PublishedText
Abstract [en]

Objective: Osteocalcin (OC), an aboundant non-collagenous bone protein, is inversely associated with parameters of glucose metabolism. Interactions between bone tissue and energy metabolism have not been thoroughly investigated during childhood. This study investigated OC, metabolic parameters and anthropometric characteristics in normal weight and overweight/obese children. Methods: This study comprised 108 (46 normal weight/62 overweight/obese) Swedish 2-9 year old children. Anthropometric data, insulin, glucose, glycosylated haemoglobin (HbA1c), HOMA index, vitamin D, adiponectin, total OC, carboxylated OC (cOC) and undercarboxylated OC (ucOC) were analysed. Results: No difference was found for total OC between the normal and overweight/obese groups, with a mean (+/- SD) value of 82.6 ( +/- 2.8) ng/mL and 77.0 ( +/- 2.4) ng/mL, (P = 0.11), respectively. Overweight children had lower cOC levels, mean 69.1 ( +/- 2.2) ng/mL, vs. normal weight children, mean 75.6 ( +/- 2.5) ng/mL (P = 0.03). The mean ucOC levels of 7.9 ( +/- 0.4) ng/mL in overweight children did not differ vs. normal weight children, mean level 7.0 (+/- 0.4) ng/mL, (P = 0.067). None of the three OC forms correlated with any of the measured parameters. Conclusions: The cOC levels were lower in overweight children. There was no correlation between the three OC forms and any of the measured anthropometric or metabolic parameters. OC has been suggested to have a possible metabolic role, but in general the current study in prepubertal children does not support the hypothesis of an association between OC and a positive metabolic profile. (C) 2016 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2016. Vol. 84, 230-236 p.
Keyword [en]
Bone; Osteocalcin; Paediatric; Fat mass; Carboxylation
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-126244DOI: 10.1016/j.bone.2016.01.008ISI: 000370914600027PubMedID: 26772621OAI: oai:DiVA.org:liu-126244DiVA: diva2:913460
Note

Funding Agencies|County Council of Ostergotland; Region Vastra Gotaland Sahlgrenska University Hospital, Sweden [72700]; Research Foundation Flanders [1.2.683.14.N.00]

Available from: 2016-03-21 Created: 2016-03-21 Last updated: 2016-03-21

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Magnusson, Per
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health SciencesDepartment of Clinical Chemistry
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