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Celiac Disease Can Be Predicted by High Levels of Anti-Tissue Transglutaminase Antibodies in Population-Based Screening
Department of Pediatrics, Clinical Sciences, Skåne University Hospital, Lund University, Lund.
Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå.
Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå.
Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå.
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2015 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 60, no 6, 787-791 p.Article in journal (Refereed) PublishedText
Abstract [en]

Objectives: The aim of the present study was to evaluate any potential correlation between anti-tissue transglutaminase antibodies of type immunoglobulin A (tTG-IgA) and the degree of gluten-induced enteropathy in children participating in a screening study for celiac disease (CD) and to assess to what extent the revised European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) guidelines cover this group of patients. Methods: The present study is a substudy of a cross-sectional CD screening study, Exploring the Iceberg of Celiacs in Sweden, a2-phased study performed during 2005 to 2006 and 2009 to 2010. The 13,279 participating children had a blood test obtained, and those with positive tTG-IgA were recommended a small intestinal biopsy. The tTG-IgA levels at the time of biopsy were compared with those at the assessment of the biopsy. Results: There were 267 children included, of whom 230 were diagnosed as having CD. Of all of the children, 67 children had low tTG-IgA levels (<5 U/mL), of whom 55% had Marsh 3 lesions. All of the children with tTG-IgA levels exceeding 10 times the upper limit of normal values of 5 U/mL, that is, 50 U/mL, were diagnosed as having CD. Lowering the cutoff to 3 U/mL, all but 1 child with 30 U/mL got CD diagnosis. Conclusions: By adopting the revised ESPGHAN criteria, biopsies could have been omitted in one-fourth of all of the patients. Our results indicate that the criteria may be useful even in screened children. Further studies are needed to confirm whether the 2012 ESPGHAN guidelines should be revised to also apply to the populations being screened.

Place, publisher, year, edition, pages
2015. Vol. 60, no 6, 787-791 p.
Keyword [en]
celiac disease; diagnosis; enteropathy; screening; serological markers
National Category
Gastroenterology and Hepatology Pediatrics
Identifiers
URN: urn:nbn:se:liu:diva-126337DOI: 10.1097/MPG.0000000000000688ISI: 000355242100016PubMedID: 25564816OAI: oai:DiVA.org:liu-126337DiVA: diva2:913689
Available from: 2016-03-22 Created: 2016-03-22 Last updated: 2016-04-08

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Högberg, LottaStenhammar, Lars
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Division of Clinical SciencesFaculty of Medicine and Health SciencesDepartment of Paediatrics in Norrköping
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Journal of Pediatric Gastroenterology and Nutrition - JPGN
Gastroenterology and HepatologyPediatrics

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