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No association between use of multivitamin supplement containing vitamin D during pregnancy and risk of Type 1 Diabetes in the child
Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Göteborg.
Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Göteborg.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg.
2015 (English)In: Pediatric Diabetes, ISSN 1399-543X, E-ISSN 1399-5448, no Nov 10Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND:

Sweden has the second highest incidence of type 1 diabetes in the world. Nutritional aspects in utero and in infancy affect the development. We conducted a survey to determine whether reported maternal use of vitamin D-containing micronutrient supplements during pregnancy was associated with the risk of developing type 1 diabetes in the child.

METHODS:

This report was based on data from the ABIS (All Babies In Southeast Sweden) study, with questionnaire data on 16 339 mother and infant pairs at birth and at 1-yr of age (n = 10 879), of whom 108 children were registered with type 1 diabetes before 14-16 yr of age. The questions 'during pregnancy, did you take any vitamin/mineral supplements?' and 'if yes, which? (open answer)' in addition to other lifestyle questions were answered. Logistic regression was performed with onset of type 1 diabetes as the dependent variable and vitamin D supplementation use as the independent variable, adjusted for relevant factors.

RESULTS:

Vitamin D supplementation during pregnancy was consumed by 9.3% of mothers whose children later got type1 diabetes and among 11.3% of those mothers whose children did not get type 1 diabetes (p = 0.532). No significant association was found between reported supplement intake of vitamin D during pregnancy and risk of type 1 diabetes, even when adjusting for factors which could influence the association.

CONCLUSION:

Maternal use of vitamin D-containing multivitamin supplements during pregnancy was not related to the risk of developing type 1 diabetes in children before 14-16 yr of age in Southeast of Sweden.

Place, publisher, year, edition, pages
2015. no Nov 10
Keyword [en]
Child, Micronutrient, Pregnancy, Supplementation, Type 1 diabetes, Vitamin D
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-126408DOI: 10.1111/pedi.12334PubMedID: 26552946OAI: oai:DiVA.org:liu-126408DiVA: diva2:914060
Available from: 2016-03-23 Created: 2016-03-23 Last updated: 2016-04-07Bibliographically approved

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Ludvigsson, Johnny
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Division of Clinical SciencesFaculty of Medicine and Health SciencesDepartment of Paediatrics in Linköping
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