liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Facing the challenges of multiscale modelling of bacterial and fungal pathogen-host interactions
Hans Knöll Institute (HKI) in Jena, Germany.
Hans Knöll Institute (HKI) in Jena, Germany.
Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
Show others and affiliations
2017 (English)In: Briefings in Functional Genomics & Proteomics, ISSN 2041-2649, E-ISSN 2041-2657, Vol. 16, no 2, 57-69 p.Article in journal (Refereed) Published
Abstract [en]

Recent and rapidly evolving progress on high-throughput measurement techniques and computational performance has led to the emergence of new disciplines, such as systems medicine and translational systems biology. At the core of these disciplines lies the desire to produce multiscale models: mathematical models that integrate multiple scales of biological organization, ranging from molecular, cellular and tissue models to organ, whole-organism and population scale models. Using such models, hypotheses can systematically be tested. In this review, we present state-of-the-art multiscale modelling of bacterial and fungal infections, considering both the pathogen and host as well as their interaction. Multiscale modelling of the interactions of bacteria, especially Mycobacterium tuberculosis, with the human host is quite advanced. In contrast, models for fungal infections are still in their infancy, in particular regarding infections with the most important human pathogenic fungi, Candida albicans and Aspergillus fumigatus. We reflect on the current availability of computational approaches for multiscale modelling of host-pathogen interactions and point out current challenges. Finally, we provide an outlook for future requirements of multiscale modelling.

Place, publisher, year, edition, pages
Oxford University Press, 2017. Vol. 16, no 2, 57-69 p.
Keyword [en]
host–pathogen interaction; infection; mathematical modelling; multiscale modelling
National Category
Genetics
Identifiers
URN: urn:nbn:se:liu:diva-126449DOI: 10.1093/bfgp/elv064PubMedID: 26857943OAI: oai:DiVA.org:liu-126449DiVA: diva2:914663
Available from: 2016-03-24 Created: 2016-03-24 Last updated: 2017-11-30Bibliographically approved

Open Access in DiVA

fulltext(571 kB)131 downloads
File information
File name FULLTEXT01.pdfFile size 571 kBChecksum SHA-512
b8e09ff9e676565496cdf80f7329b906c897544e1747b7cc8e1195016b53fa1fff9c86a606cb20accad7823f74f99e89dbf50de1a9feff4c2f85512d5c0f4b57
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Gustafsson, MikaCedersund, Gunnar

Search in DiVA

By author/editor
Gustafsson, MikaCedersund, Gunnar
By organisation
BioinformaticsFaculty of Science & EngineeringDepartment of Biomedical Engineering
In the same journal
Briefings in Functional Genomics & Proteomics
Genetics

Search outside of DiVA

GoogleGoogle Scholar
Total: 131 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 503 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf