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Vitamin D levels and depressive symptoms in patients with chronic heart failure
Linköping University, Department of Medical and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0001-7431-2873
Linköping University, Department of Medical and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Social and Welfare Studies. Linköping University, Faculty of Medicine and Health Sciences. University of Groningen, Netherlands.
Swedish Def Research Agency, Linkoping, Sweden.
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2016 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 207, 185-189 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: Vitamin D (Vit D) is suggested to play a role in the regulation of physical function as well as in depression. Since, Vit D deficiency is common in patients with heart failure (HF), this study aims to explore if Vit D levels are associated with depressive symptoms and if this association is mediated by the patients physical function. Method: 506 HF patients (mean age 71, 38% women) were investigated. Depressive symptoms and physical function were measured with the Centre for Epidemiological Studies Depression Scale and the physical function scale from the RAND-36. Vit D was measured in blood samples Results: At baseline there was no relationship between depressive symptoms and Vit D levels. However, at 18 months follow-up 29% of patients with Vit D < 50 nmol/l at baseline had depressive symptoms compared 19% of those with Vit D levels >50 nmol/l (p < 0.05). Only in patients with Vit D < 50 nmol/l, Vit D correlated significantly to physical function and depressive symptoms (r = .29, p < 0.001 and r = .20, p < 0.01). In structural equation modelling an indirect association between Vit D and depressive symptoms was found, mediated by physical function (B = 0.20). This association was only found in patients with Vit D levels <50 nmol/l. Conclusion: In HF patients with Vit D < 50 nmol/l, Vit D is associated to depressive symptoms during follow-up and this association is mediated by physical function. This relationship is not found in patients with Vitamin D level >50 nmol/l. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2016. Vol. 207, 185-189 p.
Keyword [en]
Heart failure; Vitamin D; Depression; Physical exercise
National Category
Sociology
Identifiers
URN: urn:nbn:se:liu:diva-126804DOI: 10.1016/j.ijcard.2016.01.173ISI: 000371271400062PubMedID: 26803239OAI: oai:DiVA.org:liu-126804DiVA: diva2:917727
Note

Funding Agencies|Netherlands Heart Foundation [2000Z003]

Available from: 2016-04-07 Created: 2016-04-05 Last updated: 2016-04-07

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Johansson, PeterAlehagen, UrbanJaarsma, Tiny
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Department of Medical and Health SciencesDepartment of Cardiology in LinköpingFaculty of Medicine and Health SciencesDepartment of Social and Welfare StudiesDivision of Health, Activity and Care
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International Journal of Cardiology
Sociology

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