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Light-Induced Basilar Membrane Vibrations in the Sensitive Cochlea
University of Michigan, MI 48109 USA.
Oregon Health and Science University, OR 97201 USA.
Oregon Health and Science University, OR 97201 USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Karolinska Institute, Sweden.
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2015 (English)In: MECHANICS OF HEARING: PROTEIN TO PERCEPTION, AMER INST PHYSICS , 2015, Vol. 1703, no 070005Conference paper (Refereed)Text
Abstract [en]

The exceptional sensitivity of mammalian hearing organ is attributed to an outer hair cell-mediated active process, where forces produced by sensory cells boost sound-induced vibrations, making soft sounds audible. This process is thought to be local, with each section of the hearing organ capable of amplifying sound-evoked movement, and nearly instantaneous, since amplification can work for sounds at frequencies up to 100 kHz in some species. To test these precepts, we developed a method for focally stimulating the living hearing organ with light. Light pulses caused intense and highly damped mechanical responses followed by traveling waves that developed with considerable delay. The delayed response was identical to movements evoked by click-like sounds. A physiologically based mathematical model shows that such waves engage the active process, enhancing hearing sensitivity. The experiments and the theoretical analysis show that the active process is neither local nor instantaneous, but requires mechanical waves traveling from the cochlear base toward its apex.

Place, publisher, year, edition, pages
AMER INST PHYSICS , 2015. Vol. 1703, no 070005
Series
, AIP Conference Proceedings, ISSN 0094-243X
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-127073DOI: 10.1063/1.4939379ISI: 000372065400066ISBN: 978-0-7354-1350-4OAI: oai:DiVA.org:liu-127073DiVA: diva2:919350
Conference
12th International Workshop on the Mechanics of Hearing
Available from: 2016-04-13 Created: 2016-04-13 Last updated: 2016-04-13

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Fridberger, Anders
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Division of Cell BiologyFaculty of Medicine and Health Sciences
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