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Early death among head and neck cancer patients
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Otorhinolaryngology in Linköping. Linköping University, Faculty of Medicine and Health Sciences.
Finnish Cancer Registry, Finland.
Karolinska Institute, Sweden; Karolinska Hospital, Sweden; University of Helsinki, Finland; Helsinki University Hospital, Finland.
Uppsala University, Sweden.
2016 (English)In: Current Opinion in Otolaryngology & Head and Neck Surgery, ISSN 1068-9508, E-ISSN 1531-6998, Vol. 24, no 2, 115-120 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Purpose of reviewManagement of advanced head and neck cancer (HNC) is characterized by high mortality. Furthermore, the treatment involves significant burden to patients and high costs to healthcare systems. Recognizing the risks of early death in patients with a high probability of noncurable disease is important for each individual treatment decision-making. It is thus critical to consider the benefits and side-effects of the planned treatment in relation to the expected survival and to discuss these factors with the patient. However, only few studies have documented early death in HNC patients, that is, during the first posttreatment 6 months. We performed a systematic literature review to find the incidence of this phenomenon and to outline the probable cause.Recent findingsEarly mortality in patients with HNC can be explained either by direct effect of malignant disease, may be related to comorbidities, or secondary to the treatment. These factors act together resulting in expected or unexpected early death.SummaryThe present review provides information on the mechanisms leading to early phase mortality (<6 months) after management of HNC. It also reports the incidence of this phenomenon among Finnish and Swedish patient populations.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2016. Vol. 24, no 2, 115-120 p.
Keyword [en]
chemotherapy; mortality; radiotherapy; surgery; survival
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-127042DOI: 10.1097/MOO.0000000000000236ISI: 000371888600005PubMedID: 26735585OAI: oai:DiVA.org:liu-127042DiVA: diva2:919403
Note

Funding Agencies|Helsinki University Hospital Funds

Available from: 2016-04-13 Created: 2016-04-13 Last updated: 2016-04-13

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Farnebo, Lovisa
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Division of Neuro and Inflammation ScienceDepartment of Otorhinolaryngology in LinköpingFaculty of Medicine and Health Sciences
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Current Opinion in Otolaryngology & Head and Neck Surgery
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