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Effects of salience-network-node neurofeedback training on affective biases in major depressive disorder
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Social and Affective Neuroscience (CSAN).
Stanford University, CA, USA.
Stanford University, CA, USA.
National Institutes of Health, Bethesda, MD, USA.
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2016 (English)In: Psychiatry Research: Neuroimaging, ISSN 0925-4927, E-ISSN 1872-7506, Vol. 249, 91-96 p.Article in journal (Refereed) PublishedText
Abstract [en]

Neural models of major depressive disorder (MDD) posit that over-response of components of the brains salience network (SN) to negative stimuli plays a crucial role in the pathophysiology of MDD. In the present proof-of-concept study, we tested this formulation directly by examining the affective consequences of training depressed persons to down-regulate response of SN nodes to negative material. Ten participants in the real neurofeedback group saw, and attempted to learn to down-regulate, activity from an empirically identified node of the SN. Ten other participants engaged in an equivalent procedure with the exception that they saw SN-node neurofeedback indices from participants in the real neurofeedback group. Before and after scanning, all participants completed tasks assessing emotional responses to negative scenes and to negative and positive self-descriptive adjectives. Compared to participants in the sham-neurofeedback group, from pre- to post-training, participants in the realneurofeedback group showed a greater decrease in SN-node response to negative stimuli, a greater decrease in self-reported emotional response to negative scenes, and a greater decrease in self-reported emotional response to negative self-descriptive adjectives. Our findings provide support for a neural formulation in which the SN plays a primary role in contributing to negative cognitive biases in MDD. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 249, 91-96 p.
Keyword [en]
Major depressive disorder; Neurofeedback; Functional magnetic resonance imaging; Salience network; Information processing biases
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-127261DOI: 10.1016/j.pscychresns.2016.01.016ISI: 000372526600012PubMedID: 26862057OAI: oai:DiVA.org:liu-127261DiVA: diva2:921633
Note

Funding Agencies|National Institutes of Health [P41 EB15891, F32 MH079651, R01 MH59259]

Available from: 2016-04-20 Created: 2016-04-19 Last updated: 2016-05-02Bibliographically approved

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Hamilton, Paul J.
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesCenter for Social and Affective Neuroscience (CSAN)
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ReferencesLink to record
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