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A method for monitoring of oxygen saturation changes in brain tissue using diffuse reflectance spectroscopy
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-0555-8877
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-0012-7867
2016 (English)In: Journal of Biophotonics, ISSN 1864-063X, E-ISSN 1864-0648Article in journal (Refereed) Epub ahead of printText
Abstract [en]

Continuous measurement of local brain oxygen saturation (SO2) can be used to monitor the status of brain trauma patients in the neurocritical care unit. Currently, micro-oxygen-electrodes are considered as the “gold standard” in measuring cerebral oxygen pressure (pO2), which is closely related to SO2 through the oxygen dissociation curve (ODC) of hemoglobin, but with the drawback of slow in response time. The present study suggests estimation of SO2 in brain tissue using diffuse reflectance spectroscopy (DRS) for finding an analytical relation between measured spectra and the SO2 for different blood concentrations. The P3 diffusion approximation is used to generate a set of spectra simulating brain tissue for various levels of blood concentrations in order to estimate SO2. The algorithm is evaluated on optical phantoms mimicking white brain matter (blood volume of 0.5–2%) where pO2 and temperature is controlled and on clinical data collected during brain surgery. The suggested method is capable of estimating the blood fraction and oxygen saturation changes from the spectroscopic signal and the hemoglobin absorption profile.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2016.
Keyword [en]
oxygenation, diffuse reflectance spectroscopy, hemoglobin, optical phantom, human brain
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-127362DOI: 10.1002/jbio.201500334PubMedID: 27094015OAI: oai:DiVA.org:liu-127362DiVA: diva2:922407
Available from: 2016-04-22 Created: 2016-04-22 Last updated: 2016-08-31Bibliographically approved

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Rejmstad, PeterJohansson, Johannes D.Haj-Hosseini, NedaWårdell, Karin
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