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Correction: Development of Salivary Cortisol Circadian Rhythm and Reference Intervals in Full-Term Infants
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping. Gothenburg University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
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2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 3, e0151888Article in journal, Editorial material (Other academic) Published
Abstract [en]

BACKGROUND:

Cortisol concentrations in plasma display a circadian rhythm in adults and children older than one year. Earlier studies report divergent results regarding when cortisol circadian rhythm is established. The present study aims to investigate at what age infants develop a circadian rhythm, as well as the possible influences of behavioral regularity and daily life trauma on when the rhythm is established. Furthermore, we determine age-related reference intervals for cortisol concentrations in saliva during the first year of life.

METHODS:

130 healthy full-term infants were included in a prospective, longitudinal study with saliva sampling on two consecutive days, in the morning (07:30-09:30), noon (10:00-12:00) and evening (19:30-21:30), each month from birth until the infant was twelve months old. Information about development of behavioral regularity and potential exposure to trauma was obtained from the parents through the Baby Behavior Questionnaire and the Life Incidence of Traumatic Events checklist.

RESULTS:

A significant group-level circadian rhythm of salivary cortisol secretion was established at one month, and remained throughout the first year of life, although there was considerable individual variability. No correlation was found between development of cortisol circadian rhythm and the results from either the Baby Behavior Questionnaire or the Life Incidence of Traumatic Events checklist. The study presents salivary cortisol reference intervals for infants during the first twelve months of life.

CONCLUSIONS:

Cortisol circadian rhythm in infants is already established by one month of age, earlier than previous studies have shown. The current study also provides first year age-related reference intervals for salivary cortisol levels in healthy, full-term infants.

Place, publisher, year, edition, pages
Public Library of Science , 2016. Vol. 11, no 3, e0151888
National Category
Pediatrics Psychology (excluding Applied Psychology)
Identifiers
URN: urn:nbn:se:liu:diva-127497DOI: 10.1371/journal.pone.0151888PubMedID: 26086734OAI: oai:DiVA.org:liu-127497DiVA: diva2:924379
Available from: 2016-04-28 Created: 2016-04-28 Last updated: 2017-11-30Bibliographically approved

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Ivars, KatrinNelson Follin, NinaTheodorsson, AnnetteTheodorsson, ElvarStröm, JakobMörelius, Evalotte

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Ivars, KatrinNelson Follin, NinaTheodorsson, AnnetteTheodorsson, ElvarStröm, JakobMörelius, Evalotte
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Division of Clinical SciencesFaculty of Medicine and Health SciencesDepartment of Paediatrics in LinköpingDivision of Neuro and Inflammation ScienceDepartment of NeurosurgeryDivision of Microbiology and Molecular MedicineDepartment of Clinical ChemistryDivision of Nursing ScienceDepartment of Gynaecology and Obstetrics in Linköping
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PediatricsPsychology (excluding Applied Psychology)

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