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Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression
Laureate Institute Brain Research, OK, USA.
Harvard University, MA, USA.
Laureate Institute Brain Research, OK, USA.
Harvard University, MA, USA; VA Boston Healthcare Syst, MA USA.
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2016 (English)In: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 10, 336-342 p.Article in journal (Refereed) PublishedText
Abstract [en]

Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations ofMDD, however, have thwarted development of this literature. Effects of extra-cellular free-water on the sensitivity of DTI metrics could account for some of this inconsistency. Here we investigated whether applying a free-water correction algorithm to DTI data could improve the sensitivity to detect clinical effects using DTI metrics. Only after applying this correction, we found: a) significantly decreased fractional anisotropy and axial diffusivity (AD) in the left inferior frontooccipital fasciculus (IFOF) in MDD; and b) increased self-reported stress that significantly correlated with decreased IFOF AD in depression. We estimated and confirmed the robustness of differences observed between free-water corrected and uncorrected approaches using bootstrapping. We conclude that applying a free-water correction to DTI data increases the sensitivity of DTI-based metrics to detect clinical effects in MDD. (C) 2015 The Authors. Published by Elsevier Inc.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 10, 336-342 p.
Keyword [en]
Diffusion tensor imaging; Free-water corrected DTI; Major depressive disorder; Tract-based spatial statistics; Fractional anisotropy; Axial diffusivity
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-127461DOI: 10.1016/j.nicl.2015.11.020ISI: 000373189000033PubMedID: 27006903OAI: diva2:925201

Funding Agencies|Warren Foundation

Available from: 2016-04-30 Created: 2016-04-26 Last updated: 2016-05-17Bibliographically approved

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Hamilton, Paul
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesCenter for Social and Affective Neuroscience (CSAN)
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