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Acquisition of Conditioned Responses to a Novel Alcohol-Paired Cue in Social Drinkers
Linköping University, Center for Social and Affective Neuroscience (CSAN). Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. University of Chicago, IL, USA.
University of Chicago, IL, USA.
2016 (English)In: Journal of Studies on Alcohol and Drugs, ISSN 1937-1888, E-ISSN 1938-4114, Vol. 77, no 2, 317-326 p.Article in journal (Refereed) PublishedText
Abstract [en]

Objective: This study examined the acquisition of conditioning between novel stimuli and single doses of alcohol in social drinkers. Environmental stimuli present during the consumption of alcohol or other drugs come to elicit conditioned responses that subsequently increase drug seeking. However, relatively few studies have examined the process of acquisition of these conditioned drug responses in human subjects. Method: We used a procedure previously developed to study acquisition of conditioned responses to a methamphetamine-associated cue. In the present study we applied the paradigm to alcohol, pairing de novo neutral cues with alcohol in social drinkers (N=36). We obtained measures of self-report, behavioral preference, emotional reactivity (assessed using facial electromyography), and attention to specific cues paired with administration of 0.6 g/kg 95% absolute alcohol or placebo. Results: After conditioning, participants showed an increase in attention toward the alcohol-paired cue, and this increase was associated with ratings of liking the alcohol-containing beverage during the conditioning sessions. In contrast to our previous findings with methamphetamine, the alcohol-paired cue did not elicit changes in emotional reactivity (measured by facial electromyography) or behavioral preference. Conclusions: This study extends our previous findings with a stimulant drug to. alcohol and highlights possible similarities and differences in conditioning with different classes of drugs. Conditioning with alcohol was less robust than with methamphetamine, but in both cases the conditioning that did occur was related to positive subjective drug response.

Place, publisher, year, edition, pages
Piscataway, NJ, United States: Alcohol Research Documentation, Inc. , 2016. Vol. 77, no 2, 317-326 p.
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-127447DOI: 10.15288/jsad.2016.77.317ISI: 000372769900017OAI: diva2:925212

Funding Agencies|National Institute on Drug Abuse (NIDA) [DA02812]; NIDA [DA32015]

Available from: 2016-04-30 Created: 2016-04-26 Last updated: 2016-05-03Bibliographically approved

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Mayo, Leah M.
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Center for Social and Affective Neuroscience (CSAN)Division of Neuro and Inflammation ScienceFaculty of Medicine and Health Sciences
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