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Trained immunity: a new avenue for tuberculosis vaccine development
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Radboud University of Nijmegen, Netherlands.
2016 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 279, no 4, 337-346 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Adaptive immunity towards tuberculosis (TB) has been extensively studied for many years. In addition, in recent years the profound contribution of innate immunity to host defence against this disease has become evident. The discovery of pattern recognition receptors, which allow innate immunity to tailor its response to different infectious agents, has challenged the view that this arm of immunity is nonspecific. Evidence is now accumulating that innate immunity can remember a previous exposure to a microorganism and respond differently during a second exposure. Although the specificity and memory of innate immunity cannot compete with the highly sophisticated adaptive immune response, its contribution to host defence against infection and to vaccine-induced immunity should not be underestimated and needs to be explored. Here, we present the concept of trained immunity and discuss how this may contribute to new avenues for control of TB.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 279, no 4, 337-346 p.
Keyword [en]
BCG; epigenetics; innate immunity; trained immunity; tuberculosis
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-127425DOI: 10.1111/joim.12449ISI: 000372978800002PubMedID: 26602369OAI: diva2:925263
Available from: 2016-05-01 Created: 2016-04-26 Last updated: 2016-05-17

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Lerm, Maria
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