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Cholecystokinin in plasma predicts cardiovascular mortality in elderly females
University of Copenhagen, Denmark; Aarhus University, Denmark.
University of Copenhagen, Denmark.
Linköping University, Department of Medical and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping. Linköping University, Faculty of Medicine and Health Sciences.
2016 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 209, 37-41 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: Cholecystokinin (CCK) and gastrin are related gastrointestinal hormones with documented cardiovascular effects of exogenous administration. It is unknown whether measurement of endogenous CCK or gastrin in plasma contains information regarding cardiovascular mortality. Methods: Mortality risk was evaluated using Cox proportional hazard regression and Kaplan-Meier analyses. Elderly patients in a primary care setting with symptoms of cardiac disease, i.e. shortness of breath, peripheral edema, and/or fatigue, were evaluated (n = 470). Primary care patients were followed for 13 years (from 1999); the 5-year all-cause and cardiovascular mortality was used as end point. Results: In univariate analysis, patients in the 4th CCK quartile had an increased risk of 5-year cardiovascular mortality (hazard ratio 3.9, 95% confidence interval: 2.1-7.0, p < 0.0001). In multivariate analysis including established factors associated with cardiovascular mortality, CCK concentrations in the 4th quartile were still associated with increased 5-year cardiovascular mortality risk (HR 3.1, 95% C.I.: 1.7-5.7, p = 0.0004), even when including 4th quartile NT-proBNP concentrations in the same model. We observed a marked difference between the genders, where CCK concentrations in the 4th quartile were associated with a higher 5-year cardiovascular mortality in female patients (HR 8.99, 95% C.I.: 3.49-102.82, p = 0.0007) compared to men (1.47, 95% C.I.: 0.7-3.3, p = 0.35). In contrast, no significant information was obtained from 4th quartile gastrin concentrations on 5-year cardiovascular mortality risk. Conclusions: CCK in plasma is an independent marker of cardiovascular mortality in elderly female patients. The study thus introduces measurement of plasma CCK in gender-specific cardiovascular risk assessment. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2016. Vol. 209, 37-41 p.
Keyword [en]
ANP; Atrial natriuretic peptide; Cholecystokinin; BNP; B-type natriuretic peptide; Heart failure; Prognosis
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-127412DOI: 10.1016/j.ijcard.2016.02.038ISI: 000372530700013PubMedID: 26878472OAI: diva2:925588

Funding Agencies|Novo Nordisk Foundation; Danish Center for Cellular Communication

Available from: 2016-05-02 Created: 2016-04-26 Last updated: 2016-05-02

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Alehagen, Urban
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Department of Medical and Health SciencesDepartment of Cardiology in LinköpingFaculty of Medicine and Health Sciences
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