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Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain
Karolinska Institute, Sweden.
Karolinska Institute, Sweden.
Karolinska Institute, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pharmacology. Karolinska Institute, Sweden.
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2015 (English)In: eLIFE, E-ISSN 2050-084X, ELIFE SCIENCES PUBLICATIONS LTD, SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND, ISSN 2050-084X, Vol. 4, no e08422Article in journal (Refereed) Epub ahead of printText
Abstract [en]

Organisms need to adapt to the ecological constraints in their habitat. How specific processes reflect such adaptations are difficult to model experimentally. We tested whether environmental shifts in oxygen tension lead to events in the adult newt brain that share features with processes occurring during neuronal regeneration under normoxia. By experimental simulation of varying oxygen concentrations, we show that hypoxia followed by re-oxygenation lead to neuronal death and hallmarks of an injury response, including activation of neural stem cells ultimately leading to neurogenesis. Neural stem cells accumulate reactive oxygen species (ROS) during re-oxygenation and inhibition of ROS biosynthesis counteracts their proliferation as well as neurogenesis. Importantly, regeneration of dopamine neurons under normoxia also depends on ROS-production. These data demonstrate a role for ROS-production in neurogenesis in newts and suggest that this role may have been recruited to the capacity to replace lost neurons in the brain of an adult vertebrate.

Place, publisher, year, edition, pages
Keyword [en]
cell biology; developmental biology; neural stem cells; neurogenesis; newt; reactive oxygen species; regeneration; stem cells
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URN: urn:nbn:se:liu:diva-127595DOI: 10.7554/eLife.08422ISI: 000373886700001PubMedID: 26485032OAI: diva2:925940

Funding Agencies|European Research Council (ERC); AFA Forsakring; Vetenskapsradet; Cancerfonden; Torsten Soderbergs Stiftelse; Novo Nordisk

Available from: 2016-05-03 Created: 2016-05-03 Last updated: 2016-05-24

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