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Inflammatory and endothelial markers during the menstrual cycle
Karolinska Institute, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
Karolinska Institute, Sweden.
Karolinska Institute, Sweden.
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2016 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 76, no 3, 190-194 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background The menstrual cycle exhibits a pattern of repeated inflammatory activity. The present study aims to evaluate inflammatory and endothelial markers during the two phases of a menstrual cycle. Methods The study cohort consisted of 102 women with regular menstrual cycles. Inflammatory and endothelial markers (interleukin-6 [IL-6], pentraxin-3 [PTX-3], hs-C reactive protein [hs-CRP], sE-selectin, sP-selectin, intracellular and vascular cell adhesion molecules [ICAM-1 and VCAM-1] and cathepsins L, B and S) were measured during the early follicular and the late luteal phase of a normal menstrual cycle. Results Pentraxin-3 (PTX-3) and hs-CRP were significantly higher during the follicular phase compared to the luteal phase (p < 0.001 respectively p = 0.025). The other inflammatory and endothelial markers, with the exception of cathepsin B, were higher, albeit not significantly, during the follicular phase. Conclusions Inflammatory activity, expressed mainly by members of the pentraxin family, is higher during the early follicular compared to the luteal phase. This could be associated to menstruation but the exact mechanisms behind this pattern are unclear and might involve the ovarian hormones or an effect on hepatocytes.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2016. Vol. 76, no 3, 190-194 p.
Keyword [en]
menstrual cycle; Inflammation; pentraxin
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-127556DOI: 10.3109/00365513.2015.1129670ISI: 000372195200002PubMedID: 26963835OAI: diva2:926191
Available from: 2016-05-04 Created: 2016-05-03 Last updated: 2016-09-09

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Available from 2017-03-10 13:40

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Lindahl, Tomas
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health SciencesDepartment of Clinical Chemistry
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