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Spatiotemporal Control of Amyloid-Like A Plaque Formation Using a Multichannel Organic Electronic Device
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-0302-226X
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-5582-140X
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2016 (English)In: Macromolecular materials and engineering (Print), ISSN 1438-7492, E-ISSN 1439-2054, Vol. 301, no 4, 359-363 p.Article in journal (Refereed) Published
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Abstract [en]

We herein report on an iontronic device to drive and control A1-40 and A1-42 fibril formation. This system allows kinetic control of A aggregation by regulation of H+ flows. The formed aggregates show both nanometer-sized fibril structure and microscopic growth, thus mimicking senile plaques, at the H+-outlet. Mechanistically we observed initial accumulation of A1-40 likely driven by electrophoretic migration which preceded nucleation of amyloid structures in the accumulated peptide cluster.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2016. Vol. 301, no 4, 359-363 p.
Keyword [en]
amyloid; Alzheimers disease; bioelectronics; fibrils; luminescent conjugated oligothiophene; optical probes
National Category
Electrical Engineering, Electronic Engineering, Information Engineering Chemical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-127750DOI: 10.1002/mame.201500428ISI: 000374030400001OAI: oai:DiVA.org:liu-127750DiVA: diva2:927504
Note

Funding Agencies|VINNOVA [2010-00507]; Swedish research council [2011-5804, 621-2011-3517]; Advanced Functional Materials Center at Linkoping University; Onnesjo foundation; ERC Starting Independent Researcher Grant (Project: MUMID) from the European Research Council

Available from: 2016-05-12 Created: 2016-05-12 Last updated: 2017-02-03

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Gabrielsson, ErikHammarström, PerNilsson, PeterBerggren, Magnus
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