We herein report on an iontronic device to drive and control A1-40 and A1-42 fibril formation. This system allows kinetic control of A aggregation by regulation of H+ flows. The formed aggregates show both nanometer-sized fibril structure and microscopic growth, thus mimicking senile plaques, at the H+-outlet. Mechanistically we observed initial accumulation of A1-40 likely driven by electrophoretic migration which preceded nucleation of amyloid structures in the accumulated peptide cluster.
Funding Agencies|VINNOVA [2010-00507]; Swedish research council [2011-5804, 621-2011-3517]; Advanced Functional Materials Center at Linkoping University; Onnesjo foundation; ERC Starting Independent Researcher Grant (Project: MUMID) from the European Research Council