liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Swedish children with hereditary angioedema report good overall health and quality of life despite symptoms
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. County Hospital Ryhov, Sweden.
Karolinska University Hospital, Sweden; Karolinska Institute, Sweden.
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
Show others and affiliations
2016 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 105, no 5, 529-534 p.Article in journal (Refereed) PublishedText
Abstract [en]

AimFew studies have been published on children with hereditary angioedema (HAE), an autosomal dominant disease caused by mutations on chromosome 11. This study explored various aspects of the disease in the Swedish paediatric population. MethodsA retrospective questionnaire was sent to all 36 Swedish children known to have HAE, and a physician carried out follow-up telephone interviews. ResultsMost of the questionnaires were completed by the parents of 31 (86%) children with HAE, with or without their input, at a median age of nine years (range 1-17), and the physician also interviewed 29. HAE symptoms were experienced by 23 children, including abdominal attacks (96%), skin swelling (78%) and swelling in the mouth and/or upper airways (52%). Psychological stress was the most common trigger for abdominal attacks and trauma and sports triggered skin swelling. The majority (n = 19) had access to complement-1 esterase inhibitor concentrate at home. Current health and quality of life were generally rated as good, independent of whether the child had experienced HAE symptoms or not. ConclusionMost children with HAE had experienced abdominal attacks and skin swelling, but their overall health and quality of life were generally perceived to be good.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 105, no 5, 529-534 p.
Keyword [en]
Children; Complement-1 esterase inhibitor defects; Epidemiology; Hereditary angioedema; Symptoms
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-127743DOI: 10.1111/apa.13345ISI: 000373921200028PubMedID: 26821285OAI: oai:DiVA.org:liu-127743DiVA: diva2:927517
Note

Funding Agencies|Futurum - the Academy for Health and Care; Region Jonkoping County; Linkoping University; Karolinska Institutet

Available from: 2016-05-12 Created: 2016-05-12 Last updated: 2016-05-12

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Björkander, Jan Fredrik
By organisation
Department of Clinical and Experimental MedicineFaculty of Medicine and Health SciencesDivision of Neuro and Inflammation Science
In the same journal
Acta Paediatrica
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 59 hits
ReferencesLink to record
Permanent link

Direct link