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Humoral response to influenza vaccination in relation to pre-vaccination antibody titres, vaccination history, cytomegalovirus serostatus and CD4/CD8 ratio
Jonköping University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Public Health Agency Sweden, Sweden.
Norwegian Institute Public Heatlh, Norway.
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2016 (English)In: INFECTIOUS DISEASES, ISSN 2374-4235, Vol. 48, no 6, 436-442 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background Annual vaccination against influenza virus is generally recommended to elderly and chronically ill, but the relative importance of factors influencing the outcome is not fully understood. Methods In this study of 88 individuals all aged 69 years, the increase in haemagglutinin-inhibiting (HI) antibodies to trivalent inactivated influenza vaccine was correlated with HI titres before vaccination, prior vaccinations against influenza, cytomegalovirus serostatus and, as an estimate of immune risk profile, the ratio between CD4 + and CD8 + T cells. Results Vaccine responses were impaired by high pre-existing HI antibody titres. For influenza B repeated vaccinations and an inverse CD4/CD8 ratio had a negative impact on the vaccine response. Cytomegalovirus seropositivity had no apparent effect on HI titres before or after vaccination. Conclusions It is concluded that both pre-existing HI antibodies and previous vaccinations to influenza may influence the humoral response to influenza vaccination and that a CD4/CD8 ratio < 1 may indicate an impaired ability to respond to repeated antigenic stimulation.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2016. Vol. 48, no 6, 436-442 p.
Keyword [en]
immunosenescence; cytomegalovirus; Influenza vaccination
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-127740DOI: 10.3109/23744235.2015.1135252ISI: 000373810800006PubMedID: 27030916OAI: diva2:927531

Funding Agencies|FUTURUM - The Academy for Healthcare, Region Jonkoping County; FORSS - Medical Research Council of Southeast Sweden

Available from: 2016-05-12 Created: 2016-05-12 Last updated: 2016-05-12

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Ernerudh, Jan
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Clinical Immunology and Transfusion Medicine
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