Micromechanical stimulation chips for studying mechanotransduction in micturition
2015 (English)In: 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), Institute of Electrical and Electronics Engineers (IEEE), 2015, 1672-1675 p.Conference paper (Refereed)
We have developed a micromechanical stimulation chipthat can apply physiologically relevant mechanical stimulito single cells to study mechanosensitive cells in the urinarytract. The chips comprise arrays of microactuators based onthe electroactive polymer polypyrrole (PPy). PPy offersunique possibilities and is a good candidate to provide suchphysiological mechanical stimulation, since it is driven atlow voltages, is biocompatible, and can be microfabricated.The PPy microactuators can provide mechanical stimulationat different strains and/or strain rates to single cells orclusters of cells, including controls, all integrated on onesingle chip, without the need to pre-prepare the cells. Thechips allow for in situ stimulation during live imagingstudies. The use of these devices will increase experimentalquality and reduce the number of biological samples. Theseunique tools fill an important gap in presently availabletools, since the chips provide array-based stimulationpatterns and are easily integrated in existing cell biologyequipment. These chips will generate a leap forward in ourunderstanding of the mechanisms involved inmechanotransduction in cells that may lead to breakthroughs,for instance in therapies for urinary incontinence.
Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2015. 1672-1675 p.
, 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), ISSN 2159-547X
Textile, Rubber and Polymeric Materials Urology and Nephrology
IdentifiersURN: urn:nbn:se:liu:diva-128125DOI: 10.1109/TRANSDUCERS.2015.7181264ISI: 000380461400417OAI: oai:DiVA.org:liu-128125DiVA: diva2:929460
2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS).21-25 June 2015. Anchorage, AK
FunderSwedish Research Council, VR-2014-3079