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A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans
Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)In: Metabolism: Clinical and Experimental, ISSN 0026-0495, E-ISSN 1532-8600, Vol. 65, no 6, 926-934 p.Article in journal (Refereed) Published
Abstract [en]

Objective

To study if repeated cold-exposure increases metabolic rate and/or brown adipose tissue (BAT) volume in humans when compared with avoiding to freeze.

Design

Randomized, open, parallel-group trial.

Methods

Healthy non-selected participants were randomized to achieve cold-exposure 1 hour/day, or to avoid any sense of feeling cold, for 6 weeks. Metabolic rate (MR) was measured by indirect calorimetry before and after acute cold-exposure with cold vests and ingestion of cold water. The BAT volumes in the supraclavicular region were measured with magnetic resonance imaging (MRI).

Results

Twenty-eight participants were recruited, 12 were allocated to controls and 16 to cold-exposure. Two participants in the cold group dropped out and one was excluded. Both the non-stimulated and the cold-stimulated MR were lowered within the group randomized to avoid cold (MR at room temperature from 1841 ± 199 kCal/24 h to 1795 ± 213 kCal/24 h, p = 0.047 cold-activated MR from 1900 ± 150 kCal/24 h to 1793 ± 215 kCal/24 h, p = 0.028). There was a trend towards increased MR at room temperature following the intervention in the cold-group (p = 0.052). The difference between MR changes by the interventions between groups was statistically significant (p = 0.008 at room temperature, p = 0.032 after cold-activation). In an on-treatment analysis after exclusion of two participants that reported ≥ 8 days without cold-exposure, supraclavicular BAT volume had increased in the cold-exposure group (from 0.0175 ± 0.015 l to 0.0216 ± 0.014 l, p = 0.049).

Conclusions

We found evidence for plasticity in metabolic rate by avoiding to freeze compared with cold-exposure in a randomized setting in non-selected humans.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 65, no 6, 926-934 p.
Keyword [en]
Brown adipose tissue; Cold exposure; Magnetic resonance imaging; Metabolic rate
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:liu:diva-128200DOI: 10.1016/j.metabol.2016.03.012ISI: 000376145100013PubMedID: 27173471OAI: oai:DiVA.org:liu-128200DiVA: diva2:930096
Funder
Knut and Alice Wallenberg Foundation
Note

Funding agencies: Linkoping University; County Council of Ostergotland (LUA-ALF), Sweden; Swedish Research Council [2013-4466, 2012-1652, 2014-2516]; Knut and Alice Wallenberg Foundation; Sahlgrenskas University Hospital (LUA-ALF); European Union grant (DIABAT) [HEALTH-F2-

Available from: 2016-05-22 Created: 2016-05-22 Last updated: 2017-11-30

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Romu, ThobiasDahlqvist Leinhard, OlofDahlström, NilsPersson, AndersBorga, MagnusNyström, Fredrik

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Romu, ThobiasCamilla, VavruchDahlqvist Leinhard, OlofTallberg, JoakimDahlström, NilsPersson, AndersBorga, MagnusNyström, Fredrik
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Medical InformaticsFaculty of Science & EngineeringCenter for Medical Image Science and Visualization (CMIV)Department of Medical and Health SciencesFaculty of Medicine and Health SciencesDivision of Radiological SciencesDepartment of Radiation PhysicsDepartment of Radiology in LinköpingThe Institute of TechnologyDivision of Cardiovascular MedicineDepartment of Endocrinology
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