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Assessment of advanced glycated end product accumulation in skin using auto fluorescence multispectral imaging
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-6385-6760
Institute of Clinical Physiology, Council of National Research, Pisa, Italy.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering.
2015 (English)In: Computers in Biology and Medicine, ISSN 0010-4825, E-ISSN 1879-0534Article in journal (Refereed) Epub ahead of print
Abstract [en]

Several studies have shown that advanced glycation end products (AGE) play a role in both the microvascular and macrovascular complications of diabetes and are closely linked to inflammation and atherosclerosis. AGEs accumulate in skin and can be detected using their auto fluorescence (AF).A significant correlation exists between AGE AF and the levels of AGEs as obtained from skin biopsies. A commercial device, the AGE Reader, has become available to assess skin AF for clinical purposes but, while displaying promising results, it is limited to single-point measurements performed in contact to skin tissue. Furthermore, in vivo imaging of AGE accumulation is virtually unexplored.We proposed a non-invasive, contact-less novel technique for quantifying fluorescent AGE deposits in skin tissue using a multispectral imaging camera setup (MSI) during ultraviolet (UV) exposure. Imaging involved applying a region-of-interest mask, avoiding specular reflections and a simple calibration. Results of a study conducted on 16 subjects with skin types ranging from fair to deeply pigmented skin, showed that AGE measured with MSI in forearm skin was significantly correlated with the AGE reference method (AGE Reader on forearm skin, R=0.68, p=0.005). AGE measured in facial skin was borderline significantly related to AGE Reader on forearm skin (R=0.47, p=0.078). These results support the use of the technique in devices for non-touch measurement of AGE content in either facial or forearm skin tissue over time.

Place, publisher, year, edition, pages
Elsevier, 2015.
Keyword [en]
Advanced glycation end products, Auto fluorescence, Multispectral imaging, Noninvasive, Self-monitoring
National Category
Biomedical Laboratory Science/Technology
URN: urn:nbn:se:liu:diva-128653DOI: 10.1016/j.compbiomed.2016.04.005PubMedID: 27106500OAI: diva2:931146
EU, FP7, Seventh Framework Programme, 611516
Available from: 2016-05-26 Created: 2016-05-26 Last updated: 2016-06-13Bibliographically approved

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The full text will be freely available from 2017-04-12 11:24
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