Scanning, non-contact, hybrid broadband diffuse optical spectroscopy and diffuse correlation spectroscopy system.
2016 (English)In: Biomedical Optics Express, ISSN 2156-7085, E-ISSN 2156-7085, Vol. 7, no 2, 481-498 p.Article in journal (Refereed) Published
A scanning system for small animal imaging using non-contact, hybrid broadband diffuse optical spectroscopy (ncDOS) and diffuse correlation spectroscopy (ncDCS) is presented. The ncDOS uses a two-dimensional spectrophotometer retrieving broadband (610-900 nm) spectral information from up to fifty-seven source-detector distances between 2 and 5 mm. The ncDCS data is simultaneously acquired from four source-detector pairs. The sample is scanned in two dimensions while tracking variations in height. The system has been validated with liquid phantoms, demonstrated in vivo on a human fingertip during an arm cuff occlusion and on a group of mice with xenoimplanted renal cell carcinoma.
Place, publisher, year, edition, pages
2016. Vol. 7, no 2, 481-498 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:liu:diva-128781DOI: 10.1364/BOE.7.000481PubMedID: 26977357OAI: oai:DiVA.org:liu-128781DiVA: diva2:931833