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Length adaptation of smooth muscle contractile filaments in response to sustained activation
Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, Faculty of Science & Engineering.
Graz University of Technology, Austria.
2016 (English)In: Journal of Theoretical Biology, ISSN 0022-5193, E-ISSN 1095-8541, Vol. 397, 13-21 p.Article in journal (Refereed) PublishedText
Abstract [en]

Airway and bladder smooth muscles are known to undergo length adaptation under sustained contraction. This adaptation process entails a remodelling of the intracellular actin and myosin filaments which shifts the peak of the active force-length curve towards the current length. Smooth muscles are therefore able to generate the maximum force over a wide range of lengths. In contrast, length adaptation of vascular smooth muscle has attracted very little attention and only a handful of studies have been reported. Although their results are conflicting on the existence of a length adaptation process in vascular smooth muscle, it seems that, at least, peripheral arteries and arterioles undergo such adaptation. This is of interest since peripheral vessels are responsible for pressure regulation, and a length adaptation will affect the function of the cardiovascular system. It has, e.g., been suggested that the inward remodelling of resistance vessels associated with hypertension disorders may be related to smooth muscle adaptation. In this study we develop a continuum mechanical model for vascular smooth muscle length adaptation by assuming that the muscle cells remodel the actomyosin network such that the peak of the active stress-stretch curve is shifted towards the operating point. The model is specialised to hamster cheek pouch arterioles and the simulated response to stepwise length changes under contraction. The results show that the model is able to recover the salient features of length adaptation reported in the literature.

Place, publisher, year, edition, pages
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD , 2016. Vol. 397, 13-21 p.
Keyword [en]
Continuum mechanics; Artery; Smooth muscle cell; Model; Remodelling
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:liu:diva-128721DOI: 10.1016/j.jtbi.2016.02.028ISI: 000375168300002PubMedID: 26925813OAI: oai:DiVA.org:liu-128721DiVA: diva2:932366
Note

Funding Agencies|Swedish Research Council [621-2009-3099]

Available from: 2016-06-01 Created: 2016-05-30 Last updated: 2016-06-22

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The full text will be freely available from 2017-02-27 00:00
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Stålhand, Jonas
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