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Development and Characterization of Organic Electronic Scaffolds for Bone Tissue Engineering
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, Faculty of Science & Engineering.
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
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2016 (English)In: Advanced Healthcare Materials, ISSN 2192-2640, E-ISSN 2192-2659, Vol. 5, no 12, 1505-1512 p.Article in journal (Refereed) Published
Abstract [en]

Bones have been shown to exhibit piezoelectric properties, generating electrical potential upon mechanical deformation and responding to electrical stimulation with the generation of mechanical stress. Thus, the effects of electrical stimulation on bone tissue engineering have been extensively studied. However, in bone regeneration applications, only few studies have focused on the use of electroactive 3D biodegradable scaffolds at the interphase with stem cells. Here a method is described to combine the bone regeneration capabilities of 3D-printed macroporous medical grade polycaprolactone (PCL) scaffolds with the electrical and electrochemical capabilities of the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT). PCL scaffolds have been highly effective in vivo as bone regeneration grafts, and PEDOT is a leading material in the field of organic bioelectronics, due to its stability, conformability, and biocompatibility. A protocol is reported for scaffolds functionalization with PEDOT, using vapor-phase polymerization, resulting in a conformal conducting layer. Scaffolds' porosity and mechanical stability, important for in vivo bone regeneration applications, are retained. Human fetal mesenchymal stem cells proliferation is assessed on the functionalized scaffolds, showing the cytocompatibility of the polymeric coating. Altogether, these results show the feasibility of the proposed approach to obtain electroactive scaffolds for electrical stimulation of stem cells for regenerative medicine.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016. Vol. 5, no 12, 1505-1512 p.
Keyword [en]
Bioelectronics, Stem cells, Tissue engineering, 3D scaffolds
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:liu:diva-128840DOI: 10.1002/adhm.201500874ISI: 000379550400013PubMedID: 27111453OAI: oai:DiVA.org:liu-128840DiVA: diva2:932532
Note

Funding agencies: Knut and Alice Wallenberg Foundation [KAW 2012.0302]; Nanyang Technological University

Available from: 2016-06-01 Created: 2016-06-01 Last updated: 2017-02-03

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