liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Transgenerational epigenetic inheritance: past exposures, future diseases
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
2016 (English)In: The epigenome and developmental origins of health and disease / [ed] Cheryl S. Rosenfeld, Amsterdam: Academic Press, 2016, 425-437 p.Chapter in book (Refereed)
Abstract [en]

Transgenerational epigenetic inheritance has gained increased attention due to the possibility that exposure to environmental toxicants or other stressors can induce long-lasting changes in lineages of organisms. The mechanism involves exposure of pregnant females and induction of germline epigenetic alterations in their developing embryos. This early developmental exposure generates phenotypic alterations in the adults. The germline epigenomic changes produced are then transmitted to future generations and associate with disease phenotypes in the unexposed individuals of subsequent generations. Exposures to environmental toxicants such as fungicides, pesticides, or plastic compounds have been shown in rodents to produce abnormal reproductive or metabolic phenotypes that are transgenerationally transmitted. These include transgenerational increases in the incidence of obesity, polycystic ovary syndrome (PCOS)-like symptoms, pregnancy defects, or germ cell apoptosis. Importantly, the increased incidence of these transgenerationally transmitted diseases in response to environmental exposures in animal models is sometimes drastic. The current evidence on transgenerational epigenetic inheritance observed in animal models allows predicting that environmental exposures of today's inhabitants of the world may affect the incidence of noninfectious diseases in future generations, which would be correlated with long-lasting alterations in the epigenome. The present chapter summarizes the evidence to date for transgenerational epigenetic inheritance, in both humans and animal models.

Place, publisher, year, edition, pages
Amsterdam: Academic Press, 2016. 425-437 p.
Keyword [en]
Development; DNA methylation; DOHaD; Epigenetics; Germline; Noncommunicable diseases; Transgenerational epigenetic inheritance
National Category
Pharmacology and Toxicology
URN: urn:nbn:se:liu:diva-128868ISBN: 9780128013830 (print)OAI: diva2:932989
Available from: 2016-06-02 Created: 2016-06-02 Last updated: 2016-08-19Bibliographically approved

Open Access in DiVA

No full text

Other links

find book at a swedish library/hitta boken i ett svenskt bibliotekfind book in another country/hitta boken i ett annat land

Search in DiVA

By author/editor
Guerrero-Bosagna, Carlos
By organisation
BiologyFaculty of Science & Engineering
Pharmacology and Toxicology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 10 hits
ReferencesLink to record
Permanent link

Direct link