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Quantitative MRI for Rapid and User-Independent Monitoring of Intracranial CSF Volume in Hydrocephalus
Uppsala University, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV). SyntheticMR, Linkoping, Sweden.
Umeå University, Sweden.
Uppsala University, Sweden.
2016 (English)In: American Journal of Neuroradiology, ISSN 0195-6108, E-ISSN 1936-959X, Vol. 37, no 5, 797-801 p.Article in journal (Refereed) PublishedText
Abstract [en]

BACKGROUND AND PURPOSE: Quantitative MR imaging allows segmentation of different tissue types and automatic calculation of intracranial volume, CSF volume, and brain parenchymal fraction. Brain parenchymal fraction is calculated as (intracranial volume - CSF volume) / intracranial volume. The purpose of this study was to evaluate whether the automatic calculation of intracranial CSF volume or brain parenchymal fraction could be used as an objective method to monitor volume changes in the ventricles. MATERIALS AND METHODS: A lumbar puncture with drainage of 40 mL of CSF was performed in 23 patients under evaluation for idiopathic normal pressure hydrocephalus. Quantitative MR imaging was performed twice within 1 hour before the lumbar puncture and was repeated 30 minutes, 4 hours, and 24 hours afterward. For each time point, the volume of the lateral ventricles was manually segmented and total intracranial CSF volume and brain parenchymal fraction were automatically calculated by using Synthetic MR postprocessing. RESULTS: At 30 minutes after the lumbar puncture, the volume of the lateral ventricles decreased by 5.6 +/- 1.9 mL (P < .0001) and the total intracranial CSF volume decreased by 11.3 +/- 5.6 mL (P < .001), while brain parenchymal fraction increased by 0.78% +/- 0.41% (P < .001). Differences were significant for manual segmentation and brain parenchymal fraction even at 4 hours and 24 hours after the lumbar tap. There was a significant association using a linear mixed model between change in manually segmented ventricular volume and change in brain parenchymal fraction and total CSF volume, (P < .0001). CONCLUSIONS: Brain parenchymal fraction is provided rapidly and fully automatically with Synthetic MRI and can be used to monitor ventricular volume changes. The method may be useful for objective clinical monitoring of hydrocephalus.

Place, publisher, year, edition, pages
AMER SOC NEURORADIOLOGY , 2016. Vol. 37, no 5, 797-801 p.
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-128939DOI: 10.3174/ajnr.A4627ISI: 000375820300004PubMedID: 26705322OAI: oai:DiVA.org:liu-128939DiVA: diva2:934959
Note

Funding Agencies|Independent Swedish Foundation Selanders Stiftelse grant; SyntheticMR

Available from: 2016-06-09 Created: 2016-06-07 Last updated: 2016-06-09

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Warntjes, Marcel Jan Bertus
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Clinical Physiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)
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American Journal of Neuroradiology
Clinical Medicine

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