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Biomarkers of lsystemic inflammation in farmers with musculoskeletal disorders; a plasma proteomic study
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Department Research and Dev, Sweden.
Uppsala University, Sweden.
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2016 (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 17, no 206Article in journal (Refereed) PublishedText
Abstract [en]

Background: Farmers have an increased risk for musculoskeletal disorders (MSD) such as osteoarthritis of the hip, low back pain, and neck and upper limb complaints. The underlying mechanisms are not fully understood. Workrelated exposures and inflammatory responses might be involved. Our objective was to identify plasma proteins that differentiated farmers with MSD from rural referents. Methods: Plasma samples from 13 farmers with MSD and rural referents were included in the investigation. Gel based proteomics was used for protein analysis and proteins that differed significantly between the groups were identified by mass spectrometry. Results: In total, 15 proteins differed significantly between the groups. The levels of leucine-rich alpha-2-glycoprotein, haptoglobin, complement factor B, serotransferrin, one isoform of kininogen, one isoform of alpha-1-antitrypsin, and two isoforms of hemopexin were higher in farmers with MSD than in referents. On the other hand, the levels of alpha-2-HS-glycoprotein, alpha-1B-glycoprotein, vitamin D-binding protein, apolipoprotein A1, antithrombin, one isoform of kininogen, and one isoform of alpha-1-antitrypsin were lower in farmers than in referents. Many of the identified proteins are known to be involved in inflammation. Conclusions: Farmers with MSD had altered plasma levels of protein biomarkers compared to the referents, indicating that farmers with MSD may be subject to a more systemic inflammation. It is possible that the identified differences of proteins may give clues to the biochemical changes occurring during the development and progression of MSD in farmers, and that one or several of these protein biomarkers might eventually be used to identify and prevent work-related MSD.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD , 2016. Vol. 17, no 206
Keyword [en]
Musculoskeletal disorder; Farmers; Proteomic; Systemic inflammation; Occupational medicine
National Category
Basic Medicine
URN: urn:nbn:se:liu:diva-128936DOI: 10.1186/s12891-016-1059-yISI: 000375761500001PubMedID: 27160764OAI: diva2:934962

Funding Agencies|Swedish Farmers Foundation for Agricultural Research [H0935072]; Swedish Rheumatism Association [R-420491]

Available from: 2016-06-09 Created: 2016-06-07 Last updated: 2016-06-27

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Ghafouri, BijarCarlsson, AndersTagesson, Christer
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Division of Community MedicineFaculty of Medicine and Health SciencesPain and Rehabilitation CenterDivision of Neuro and Inflammation ScienceOccupational and Environmental Medicine Center
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BMC Musculoskeletal Disorders
Basic Medicine

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