liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Shape engineering boosts antibacterial activity of chitosan coated mesoporous silica nanoparticle doped with silver: a mechanistic investigation
Abo Akad University, Finland; Abo Akad University, Finland.
Bose Institute, India.
Abo Akad University, Finland.
Linköping University, Department of Physics, Chemistry and Biology, Nanostructured Materials. Linköping University, Faculty of Science & Engineering.
Show others and affiliations
2016 (English)In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 4, no 19, 3292-3304 p.Article in journal (Refereed) PublishedText
Abstract [en]

In this study, mesoporous silica nanoparticles (MSPs) of different size and shape were developed, and their surface coatings were utilized to study their differential effects in enhancing antibacterial activity. In brief, MSPs with three different aspect ratios (1, 2 and 4) were prepared, doped with silver ions and finally coated with the polymer chitosan. Both Gram-positive and Gram-negative bacteria were treated with the MSPs. Results indicate that silver ion doped and chitosan coated MSPs with the aspect ratio of 4 (Cht/MSP4:Ag+) have the highest antimicrobial activity among the prepared series. Further studies revealed that Cht/MSP4:Ag+ was most effective against Escherichia coli (E.coli) and least effective against Vibrio cholerae (V. cholerae). To investigate the detailed inhibition mechanism of the MSPs, the interaction of the nanoparticles with E.coli membranes and its intracellular DNA was assessed using various spectroscopic and imaging-based techniques. Furthermore, to increase the efficiency of the MSPs, a combinatorial antibacterial strategy was also explored, where nanoparticles, in combination with kanamycin (antibiotic), were used against Vibrio Cholerae (V. cholerae). Toxicity screening of these on MSPs was conducted on Caco-2 cells, and the results show that the dose used for antibacterial screening is below the limit of the toxicity threshold. Our findings show that both shape and surface engineering contribute positively towards killing bacteria, and the newly developed silver ion-doped and chitosan-coated MSPs have good potential as antimicrobial nanomaterials.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2016. Vol. 4, no 19, 3292-3304 p.
National Category
Materials Chemistry
URN: urn:nbn:se:liu:diva-129179DOI: 10.1039/c5tb02526eISI: 000376039100014OAI: diva2:935988

Funding Agencies|CSIR, India; J. C. Bose national fellowship; Nanolith Sverige AB; Linnaeus environment Lili-NFM

Available from: 2016-06-13 Created: 2016-06-13 Last updated: 2016-07-07

Open Access in DiVA

The full text will be freely available from 2017-04-07 16:34
Available from 2017-04-07 16:34

Other links

Publisher's full text

Search in DiVA

By author/editor
Björk, EmmaOdén, Magnus
By organisation
Nanostructured MaterialsFaculty of Science & Engineering
In the same journal
Journal of materials chemistry. B
Materials Chemistry

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 7 hits
ReferencesLink to record
Permanent link

Direct link