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Neuronal Cell Fate Specification by the Convergence of Different Spatiotemporal Cues on a Common Terminal Selector Cascade
University of Autonoma Madrid, Spain.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
University of Autonoma Madrid, Spain.
University of Autonoma Madrid, Spain.
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2016 (English)In: PLoS biology, ISSN 1544-9173, E-ISSN 1545-7885, Vol. 14, no 5, e1002450- p.Article in journal (Refereed) PublishedText
Abstract [en]

Specification of the myriad of unique neuronal subtypes found in the nervous system depends upon spatiotemporal cues and terminal selector gene cascades, often acting in sequential combinatorial codes to determine final cell fate. However, a specific neuronal cell subtype can often be generated in different parts of the nervous system and at different stages, indicating that different spatiotemporal cues can converge on the same terminal selectors to thereby generate a similar cell fate. However, the regulatory mechanisms underlying such convergence are poorly understood. The Nplp1 neuropeptide neurons in the Drosophila ventral nerve cord can be subdivided into the thoracic-ventral Tv1 neurons and the dorsal-medial dAp neurons. The activation of Nplp1 in Tv1 and dAp neurons depends upon the same terminal selector cascade: colamp;gt;ap/eyaamp;gt;dimmamp;gt;Nplp1. However, Tv1 and dAp neurons are generated by different neural progenitors (neuroblasts) with different spatiotemporal appearance. Here, we find that the same terminal selector cascade is triggered by Kr/pdmamp;gt;grn in dAp neurons, but by Antp/hth/exd/lbe/cas in Tv1 neurons. Hence, two different spatiotemporal combinations can funnel into a common downstream terminal selector cascade to determine a highly related cell fate.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE , 2016. Vol. 14, no 5, e1002450- p.
National Category
Developmental Biology
URN: urn:nbn:se:liu:diva-129501DOI: 10.1371/journal.pbio.1002450ISI: 000376906100001PubMedID: 27276273OAI: diva2:940131

Funding Agencies|Swedish Research Council (VR-NT) [621-2010-5214]; Wallenberg Foundation [KAW2012.0101]; Swedish Cancer Foundation [120531]; Spanish Ministerio de Economia y Competitividad [BFU2013-43858-P]

Available from: 2016-06-20 Created: 2016-06-20 Last updated: 2016-07-13

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