Environmental risk factors for type 1 diabetes
2016 (English)In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 387, no 10035, 2340-2348 p.Article in journal (Refereed) PublishedText
The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to beta cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens.
Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2016. Vol. 387, no 10035, 2340-2348 p.
Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:liu:diva-129471DOI: 10.1016/S0140-6736(16)30507-4ISI: 000376969100037OAI: oai:DiVA.org:liu-129471DiVA: diva2:940676
Funding Agencies|National Institutes of Health [DK32493]; Juvenile Diabetes Research Foundation [17-2013-535]; Swedish Child Diabetes Foundation (Barndiabetesfonden); JDF-Wallenberg [K98-99JD-12813-01A]; Swedish Medical Research Council (MFR) [K99-72X-11242-05A]; Research Council of Southeast Sweden2016-06-212016-06-202016-06-21