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Environmental risk factors for type 1 diabetes
University of Colorado, CO USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
2016 (English)In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 387, no 10035, 2340-2348 p.Article in journal (Refereed) PublishedText
Abstract [en]

The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to beta cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2016. Vol. 387, no 10035, 2340-2348 p.
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:liu:diva-129471DOI: 10.1016/S0140-6736(16)30507-4ISI: 000376969100037OAI: diva2:940676

Funding Agencies|National Institutes of Health [DK32493]; Juvenile Diabetes Research Foundation [17-2013-535]; Swedish Child Diabetes Foundation (Barndiabetesfonden); JDF-Wallenberg [K98-99JD-12813-01A]; Swedish Medical Research Council (MFR) [K99-72X-11242-05A]; Research Council of Southeast Sweden

Available from: 2016-06-21 Created: 2016-06-20 Last updated: 2016-06-21

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Ludvigsson, Johnny
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Division of Clinical SciencesFaculty of Medicine and Health SciencesDepartment of Paediatrics in Linköping
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