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Non-viable sperm in the ejaculate: Lethal escorts for Contemporary viable sperm
University of Murcia, Spain.
University of Murcia, Spain.
University of Murcia, Spain.
University of Murcia, Spain.
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2016 (English)In: Animal Reproduction Science, ISSN 0378-4320, E-ISSN 1873-2232, Vol. 169, 24-31 p.Article in journal (Refereed) PublishedText
Abstract [en]

Non-viable sperm ("dead sperm") are present invariable numbers in mammalian ejaculates and their number increase substantially when semen is stored, particularly cryopreserved. This review comparatively highlights, with experimental data in porcine, the role-played by non-viable sperm in the outcome of semen used in assisted reproductive technologies. As well, the review discusses our current understanding of their origin and the pathways involved when their large numbers negative influence the functional lifespan of contemporary viable sperm to eventually cause irreversible dysfunction that reduces their fertility potential and their ability to develop healthy embryos. Finally, it highlights procedures currently available to mitigate these harmful effects. (C) 2016 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2016. Vol. 169, 24-31 p.
Keyword [en]
Dead sperm; Apoptosis; Necrosis; Oxidative stress; Livestock species
National Category
Other Veterinary Science
URN: urn:nbn:se:liu:diva-129667DOI: 10.1016/j.anireprosci.2016.02.028ISI: 000377232600005PubMedID: 26948922OAI: diva2:943162

Funding Agencies|European Regional Development Fund; Spanish Government (MINECO-FEDER) [AGL2012-39903, MINECO AGL2015-69738-R]; Seneca Foundation of Murcia [19892/GERM/15]; Swedish Research Council VR, Stockholm, Sweden [2011-6353]; Swedish Research Council FORMAS, Stockholm, Sweden [2011-512]; Swedish Research Council FORSS, Stockholm, Sweden [312971]

Available from: 2016-06-27 Created: 2016-06-23 Last updated: 2016-08-21

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The full text will be freely available from 2017-03-03 17:34
Available from 2017-03-03 17:34

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Rodriguez-Martinez, Heriberto
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Division of Clinical SciencesFaculty of Medicine and Health Sciences
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