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Long-term outcomes of destructive seronegative (rheumatoid) arthritis - description of four clinical cases
Jyvaskyla Central Hospital, Finland.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Rheumatology.
Jyvaskyla Central Hospital, Finland.
Jyvaskyla Central Hospital, Finland.
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2016 (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 17, 246Article in journal (Refereed) PublishedText
Abstract [en]

Background: Seronegative rheumatoid arthritis is associated with a milder course of progression compared to seropositive disease. However, long-term follow-up data of the clinical course of seronegative rheumatoid arthritis are sparse. Here we describe four cases with a rare disease entity of aggressive destructive seronegative (rheumatoid) arthritis with 20-35 years of follow-up. Case presentation: The four cases are women with an initial presentation of seronegative rheumatoid arthritis in 1980-1996 and have received disease-modifying anti-rheumatic drugs since the diagnosis. In all cases, the condition has been refractory to treatments and evolved into a severe disease with destructions of the wrists, sub-talar and ankle joints, as well as large joints but not small joints of fingers and toes. All cases are negative with regard to rheumatoid factor, anti-cyclic citrullinated peptide antibodies and antibodies against carbamylated proteins. Conclusions: This report adds to the existing literature, making the reader aware of this sub-type of inflammatory arthritis which despite being seronegative, can have devastating disease consequences. The report highlights the need for further research into this field in order to better understand this disease sub-type, the pathogenesis, disease course and outcomes.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD , 2016. Vol. 17, 246
Keyword [en]
Rheumatoid arthritis; Seronegative; Erosions; Outcomes
National Category
Rheumatology and Autoimmunity
URN: urn:nbn:se:liu:diva-129665DOI: 10.1186/s12891-016-1067-yISI: 000377245800001PubMedID: 27256084OAI: diva2:943222

Funding Agencies|Swedish Society for Medical Research; EULAR Scientific Training bursary

Available from: 2016-06-27 Created: 2016-06-23 Last updated: 2016-07-26

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Sjöwall, Christopher
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Rheumatology
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