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Left ventricular hypertrophy in adults with previous repair of coarctation of the aorta; association with systolic blood pressure in the high normal range
Umeå University, Sweden.
Gothenburg University, Sweden.
Lund University, Sweden.
Karolinska Institute, Sweden.
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2016 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 218, 59-64 p.Article in journal (Refereed) PublishedText
Abstract [en]

Background: Arterial hypertension is common in adults with repaired coarctation of the aorta (CoA). The associations between the diagnosis of hypertension, actual blood pressure, other factors affecting left ventricular overload, and left ventricular hypertrophy (LVH) are not yet fully explored in this population. Material and results: From the national register for congenital heart disease, 506 adult patients (amp;gt;= 18 years old) with previous repair of CoA were identified (37.0% female, mean age 35.7 +/- 13.8 years, with an average of 26.8 +/- 12.4 years post repair). Echocardiographic data were available for all patients, and showed LVH in 114 (22.5%) of these. Systolic blood pressure (SBP) (mm Hg) (OR 1.02, CI 1.01-1.04), aortic valve disease, (OR 2.17, CI 1.33-3.53), age (years) (OR 1.03, CI 1.01-1.05), diagnosis of arterial hypertension (OR 3.02, CI 1.81-5.02), and sex (female) (OR 0.41, CI 0.24-0.72) were independently associated with LVH. There was an association with LVH at SBP within the upper reference limits [ 130, 140] mm Hg (OR 2.23, CI 1.05-4.73) that further increased for SBP amp;gt; 140 mm Hg (OR 8.02, CI 3.76-17.12). Conclusions: LVH is common post repair of CoA and is associated with SBP even below the currently recommended target level. Lower target levels may therefore become justified in this population. ORCID Id: 0000-0003-0976-6910 (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2016. Vol. 218, 59-64 p.
Keyword [en]
CoA; Hypertension; Left ventricular hypertrophy; Adult congenital heart disease
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-130115DOI: 10.1016/j.ijcard.2016.05.033ISI: 000377856300010PubMedID: 27232912OAI: oai:DiVA.org:liu-130115DiVA: diva2:948610
Note

Funding Agencies|Swedish Heart and Lung Foundation [2013074, 20150579]; Heart Foundation of Northern Sweden; Umea University; County Council of Vasterbotten

Available from: 2016-07-12 Created: 2016-07-11 Last updated: 2016-07-12

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Nielsen, Niels Erik
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Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of Cardiology in Linköping
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International Journal of Cardiology
Cardiac and Cardiovascular Systems

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